Prediction of genetic risk for dyslipidemia
Prediction of genetic risk for dyslipidemia
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DOI：
10.1016/j.ygeno.2007.08.001
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发表时间：
2007-11-01
期刊：
影响因子：
4.4
通讯作者：
Nozawa, Yoshinori
中科院分区：
文献类型：
--
作者：
Yamada, Yoshiji;Matsuo, Hitoshi;Nozawa, Yoshinori
本研究的目的是确定导致血脂异常易感性的遗传变异。总共对来自两个独立群体的 5213 名个体进行了检查：受试者组 A 包括 3794 名访问过参与医院的个体；主题组 B 由 1419 名社区居住的老年人组成。确定了 65 个候选基因的 100 个多态性的基因型。 X 2 检验和多变量logistic回归分析显示APOA5、APOC3、APOA1、ACAT2和LPL的7个多态性与高甘油三酯血症显着相关，APOA5、LIPC和CYP3A4的6个多态性与低FIDL-胆固醇显着相关，APOE和CCR2的3个多态性与高LDL-胆固醇显着相关。 为了验证这些关联，在主题组 B 中检查了相同的多态性。APOA5、APOC3、APOA1 和 LPL 的六种多态性再次与高甘油三酯血症显着相关，APOA5 的三种多态性与低 HDL-胆固醇有关，APOE 的两种多态性与高 LDL-胆固醇有关。在两个受试者组中，这些相应多形性的基因型之间的血清甘油三酯、HDL-胆固醇和LDL-胆固醇浓度显着不同。这些结果表明，在日本人中，APOA5、APOC3、APOA1和LPL的多态性是高甘油三酯血症的决定因素，APOA5和APOE的多态性分别是日本人低HDL胆固醇和高LDL胆固醇的决定因素。 (c) 2007 Elsevier Inc. 保留所有权利。
The purpose of the present study was to identify genetic variants that confer susceptibility to dyslipidemia. A total of 5213 individuals from two independent populations were examined: Subject panel A comprised 3794 individuals who visited participating hospitals; subject panel B comprised 1419 community-dwelling elderly individuals. The genotypes for 100 polymorphisms of 65 candidate genes were determined. The X 2 test and multivariable logistic regression analysis revealed that seven polymorphisms of APOA5, APOC3, APOA1, ACAT2, and LPL were significantly associated with hypertriglyceridemia, six polymorphisms of APOA5, LIPC, and CYP3A4 with low FIDL-cholesterol, and three polymorphisms of APOE and CCR2 with high LDL-cholesterol in subject panel A. For validation of these associations, the same polymorphisms were examined in subject panel B. Six polymorphisms of APOA5, APOC3, APOA1, and LPL were again significantly associated with hypertriglyceridemia, three polymorphisins of APOA5 with low HDL-cholesterol, and two polymorphisms of APOE with high LDL-cholestero). Serum triglyceride, HDL-cholesterol, and LDL-cholesterol concentrations differed significantly among genotypes of these corresponding polyrriorphisms in both Subject panels. These results indicate that polymorphisins of APOA5, APOC3, APOA1, and LPL are determinants of hypertriglyceridemia and that those of APOA5 and APOE are determinants of low HDL-cholesterol and high LDL-cholesterol, respectively, in Japanese individuals. (c) 2007 Elsevier Inc. All rights reserved.