Recent advances in distal tubular potassium handling.
Recent advances in distal tubular potassium handling.
复制标题
远端肾小管钾处理的最新进展。
DOI：
10.1152/ajprenal.00742.2010
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Huang,Chou-Long
中科院分区：
文献类型：
--
作者：
Rodan,AylinR;Cheng,Chih-Jen;Huang,Chou-Long
It is well known that sodium reabsorption and aldosterone play important roles in potassium secretion by the aldosterone-sensitive distal nephron. Sodium- and aldosterone-independent mechanisms also exist. This review focuses on some recent studies that provide novel insights into the sodium- and aldosterone-independent potassium secretion by the aldosterone-sensitive distal nephron. In addition, we discuss a study reporting on the regulation of the mammalian potassium kidney channel ROMK by intracellular and extracellular magnesium, which may be important in the pathogenesis of persistent hypokalemia in patients with concomitant potassium and magnesium deficiency. We also discuss outstanding questions and propose working models for future investigation.
