HEMODYNAMIC-EFFECTS OF COFFEE AND CAFFEINE IN NORMAL VOLUNTEERS - A PLACEBO-CONTROLLED CLINICAL-STUDY
HEMODYNAMIC-EFFECTS OF COFFEE AND CAFFEINE IN NORMAL VOLUNTEERS - A PLACEBO-CONTROLLED CLINICAL-STUDY
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DOI：
10.1111/j.1365-2796.1991.tb00385.x
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发表时间：
1991-06-01
影响因子：
11.1
通讯作者：
PESSINA, AC
中科院分区：
文献类型：
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作者：
CASIGLIA, E;BONGIOVI, S;PESSINA, AC
在15名健康的非咖啡饮用者中研究了意大利咖啡和200 mg纯化咖啡因的急性血液动力学效应，并与服用安慰剂的个体进行了比较（高脱咖啡因咖啡用于普通咖啡，中国苦提取物用于咖啡因）。在饮用咖啡和咖啡因前以及饮用咖啡因后30、60、90和120 min，测量静息血流和血压，并计算手臂外周阻力;在饮用咖啡因前以及饮用咖啡因后60和120 min进行超声心动图检查。咖啡和咖啡因均显著降低静息血流，并增加外周阻力。收缩压升高10%，舒张压升高5%，持续至少2小时。没有发现心率或心肌收缩力的变化。安慰剂治疗后没有观察到任何影响。结论是意大利咖啡和咖啡因通过血管收缩增加血压。
The acute haemodynamic effects of Italian coffee and 200 mg purified caffeine were investigated in 15 healthy non-coffee-drinkers compared to individuals who consumed placebo (highly decaffeinated coffee for regular coffee, and china bitter extract for caffeine). Before coffee and caffeine consumption and 30, 60, 90 and 120 min afterwards, rest flow and blood pressure were measured, and peripheral resistance in the arm was calculated; an echocardiogram was also performed before and 60 and 120 min after caffeine consumption. Both coffee and caffeine significantly decreased rest flow, and increased peripheral resistance. Systolic blood pressure increased by 10 % and diastolic pressure increased by 5 % for at least 2 h. No variation in heart rate or cardiac contractility was found. No effects were observed after placebo treatment. It is concluded that Italian coffee and caffeine increase blood pressure via vasoconstriction.