Cell Sheet-Based Tissue Engineering for Mesothelial Cell Injury
Cell Sheet-Based Tissue Engineering for Mesothelial Cell Injury
复制标题
DOI：
10.1159/000380971
复制
发表时间：
2015-01-01
期刊：
影响因子：
--
通讯作者：
Nitta, Kosaku
中科院分区：
文献类型：
--
作者：
Kawanishi, Kunio;Nitta, Kosaku
间皮细胞是腹膜的组成部分，在维持其结构和功能方面起着重要作用。已经进行了许多研究来评估间皮细胞再生和转分化的能力。间皮细胞也参与修复手术或腹膜炎造成的腹膜损伤。以前的细胞片工程研究已经使移植保留其功能的细胞成为可能，并且在细胞片层中堆叠不同类型的细胞也成为可能。间皮细胞移植作为实现腹膜再生的手段，需要在脏腹膜的表面积大且间皮细胞损伤面积小的条件下进行。在这一章中，我们将解释细胞片工程作为一种技术，用于移植细胞，其中各种细胞间粘附和细胞膜分子保持完整，并将此技术应用于腹膜再生。(C)2015 S. Karger AG，巴塞尔
Mesothelial cells are an integral part of the peritoneum and play an important role in maintaining its structure and functions. A number of studies have been performed to evaluate the ability of mesothelial cells to regenerate and transdifferentiate. Mesothelial cells are also involved in repairing the damage to the peritoneum as a result of surgery or peritonitis. Previous cell sheet engineering research has made it possible to transplant cells that retain their function, and stacking different types of cells in cell sheet layers has also become possible. Mesothelial cell transplantation as a means of achieving peritoneal regeneration needs to be performed under conditions in which the surface area of the visceral peritoneum is large and the area of mesothelial cell damage is small. In this chapter, we explain cell sheet engineering as a technology for transplanting cells in which a variety of intercellular adhesion and cell membrane molecules remain intact and the application of this technology to peritoneal regeneration. (C) 2015 S. Karger AG, Basel