Role of integrins in angiogenesis
Role of integrins in angiogenesis
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DOI：
10.1016/s0959-8049(96)00381-4
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发表时间：
1996-12-01
影响因子：
8.4
通讯作者：
Brooks, PC
中科院分区：
文献类型：
--
作者：
Brooks, PC
血管生成，或从预先存在的血管发育出新血管，是一个严格调控的过程，在各种正常生理事件中起关键作用，包括滋养层植入、伤口愈合和胚胎发育[同上]。然而，不受控制的新生血管形成可导致许多病理过程，例如类风湿性关节炎、糖尿病性视网膜病变和肿瘤生长和转移[1 -4]。因此，鉴定调节血管生成的分子，并进而了解这些分子在血管生成级联反应中的功能，是现代血管生物学领域研究人员面临的主要问题。血管生成级联反应血管生成需要多种分子的合作，这些分子调节细胞过程，如细胞外基质（ECM）重塑、侵袭、迁移和增殖。为简单起见，血管生成可被组织成三个概括的阶段，包括起始阶段、增殖/侵袭阶段和分化/成熟阶段（图1）。然而，重要的是要指出，虽然这些是不同的细胞过程，但它们并不是孤立发生的，而是在生物事件的连续体中相互关联的。血管生成的起始阶段可以通过多种血管生成细胞因子和其他生理介质激活血管细胞来完成。已知促进血管生成的更充分表征的生长因子的部分列表包括碱性成纤维细胞生长因子（bFGF）、血管内皮生长因子（VEGF）、血小板衍生的内皮细胞生长因子（PDECGF）和肿瘤坏死因子α（TNF-α）[5，61]。这些细胞因子和其他血管生成分子可以从许多来源释放，包括炎性细胞、肥大细胞、巨噬细胞以及各种肿瘤细胞。
ANGIOGENESIS, OR the development of new blood vessels from pre-existing vessels, is a tightly regulated process that plays a critical role in a variety of normal physiological events, including trophoblast implantation, wound healing and embryonic development [Id]. However, uncontrolled neovascularisation can contribute to a number of pathological processes such as rheumatoid arthritis, diabetic retinopathy and tumour growth and metastasis [l-4]. Therefore, the identification of molecules that regulate angiogenesis, and in turn, understanding how these molecules function during the angiogenic cascade, are major concerns facing researchers in the field of modem vascular biology.THE ANGIOGENIC CASCADE Angiogenesis requires the co-operation of a variety of molecules that regulate cellular processes such as extracellular matrix (ECM) remodelling, invasion, migration and proliferation. For simplicity, angiogenesis can be organised into three generalised stages including an initiation phase, a proliferative/invasive phase and a differentiation/maturation phase (Figure 1). However, it is important to point out that while these are distinct cellular processes, they do not occur in isolation, but rather are interconnected in a continuum of biological events. The initiation phase of angiogenesis can be accomplished by the activation of vascular cells by a variety of angiogenic cytokines and other physiological mediators. A partial list of the more well-characterised growth factors known to promote angiogenesis include basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), platelet-derived endothelial-cell growth factor (PDECGF) and tumour necrosis factor alpha (TNF-c ()[5, 61. These cytokines and other angiogenic molecules can be released from a number of sources including inflammatory cells, mast cells, macrophages as well as a variety of tumour cells.