Deep tissue photoacoustic imaging using a miniaturized 2-D capacitive micromachined ultrasonic transducer array.
Deep tissue photoacoustic imaging using a miniaturized 2-D capacitive micromachined ultrasonic transducer array.
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DOI：
10.1109/tbme.2012.2183593
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Gambhir SS
中科院分区：
文献类型：
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作者：
Kothapalli SR;Ma TJ;Vaithilingam S;Oralkan O;Khuri-Yakub BT;Gambhir SS
在本文中，我们演示了3-D光声成像（派）的光吸收物体嵌入深为5厘米内的强光学散射幻影使用小型化（4 mm × 4 mm × 500 µm），2-D电容式微机械超声换能器（CMUT）阵列的16 × 16元素与5.5 MHz的中心频率。放置在不同深度的对象的二维断层图像和3-D体积图像。此外，我们研究了基于CMUT的派对体模内5 cm深度处吲哚菁绿色染料浓度的灵敏度。在优化的实验条件下，5 cm深度的物体可以成像，SNR约为35 dB，空间分辨率约为500 µm。结果表明，CMUT与集成的前端放大器电路是一个有吸引力的选择，实现相对较高的深度灵敏度派。
In this paper, we demonstrate 3-D photoacoustic imaging (PAI) of light absorbing objects embedded as deep as 5 cm inside strong optically scattering phantoms using a miniaturized (4 mm × 4 mm × 500 µm), 2-D capacitive micromachined ultrasonic transducer (CMUT) array of 16 × 16 elements with a center frequency of 5.5 MHz. Two-dimensional tomographic images and 3-D volumetric images of the objects placed at different depths are presented. In addition, we studied the sensitivity of CMUT-based PAI to the concentration of indocyanine green dye at 5 cm depth inside the phantom. Under optimized experimental conditions, the objects at 5 cm depth can be imaged with SNR of about 35 dB and a spatial resolution of approximately 500 µm. Results demonstrate that CMUTs with integrated front-end amplifier circuits are an attractive choice for achieving relatively high depth sensitivity for PAI.