Metabolic neuroimaging of the cervical spinal cord in patients with compressive myelopathy: a high-resolution positron emission tomography study
Metabolic neuroimaging of the cervical spinal cord in patients with compressive myelopathy: a high-resolution positron emission tomography study
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DOI：
10.3171/spi.2004.1.1.0072
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发表时间：
2004-07-01
影响因子：
2.8
通讯作者：
Baba, H
中科院分区：
文献类型：
--
作者：
Uchida, K;Kobayashi, S;Baba, H
Object.作者进行了一项研究，以检查高分辨率[（18）F]氟脱氧葡萄糖（FDG）-正电子发射断层扫描（PET）是否可用于可视化与不同程度压迫相关的颈脊髓功能恶化，并确定其在评估压迫性脊髓病期间的潜在有用性。在23例需要脊髓病减压手术的患者中进行了FDG-PET。将术前高分辨率FDG-PET的结果与神经功能评分和磁共振（MR）成像结果进行比较。术前颈髓FDG利用率的标准化摄取值（SUV）与术前（r = 0.497，p = 0.016）和术后（r = 0.595，p = 0.003）神经功能评分以及术后神经功能改善率相关（r = 0.538，p = 0.008）。FDG利用率与T2加权像上的高信号强度无关。这些结果的分析表明，高分辨率FDG-PET成像提供了有用的定性和定量评估受损的颈髓的代谢活动受损，与神经功能障碍的严重程度密切相关。
Object. The authors conducted a study to examine whether high-resolution [(18)F]fluorodeoxyglucose (FDG)-positron emission tomography (PET) could be used to visualize deterioration of cervical spinal cord function associated with various degrees of compression and to determine its potential usefulness during assessment of compressive myelopathy.Methods. In 23 patients requiring decompressive surgery for myelopathy FDG-PET was performed. The preoperative findings of high-resolution FDG-PET were compared with the neurological scores and magnetic resonance (MR) imaging findings. The preoperative standardized uptake value (SUV) of FDG utilization rate of the cervical cord correlated with the pre- (r = 0.497, p = 0.016) and postoperative neurological scores (r = 0.595, p = 0.003), as well as with the rate of neurological improvement postoperatively (r = 0.538, p = 0.008). The FDG utilization rate did not correlate with the high signal intensity on T(2)-weighted MR images.Conclusions. Analysis of these results indicates that high-resolution FDG-PET imaging provides useful qualitative and quantitative estimates of impaired metabolic activity of the compromised cervical cord that correlate closely with the severity of neurological dysfunction.