Tau protein phosphorylated at threonine 181 in CSF as a neurochemical biomarker in Alzheimer's disease - Original data and review of the literature
Tau protein phosphorylated at threonine 181 in CSF as a neurochemical biomarker in Alzheimer's disease - Original data and review of the literature
复制标题
DOI：
10.1385/jmn:23:1-2:115
复制
发表时间：
2004-01-01
影响因子：
3.1
通讯作者：
Wiltfang, L
中科院分区：
文献类型：
--
作者：
Lewczuk, P;Esselmann, H;Wiltfang, L
用双抗体夹心酶联免疫吸附试验检测了一组经神经化学检查确诊为阿尔茨海默病患者(AD，n=9，年龄51~89岁)和性别、年龄匹配的非痴呆对照组(n=9，年龄52~81岁)脑脊液中总Tau和苏氨酸(181位[pTau181]位)磷酸化Tau的浓度。AD组两种生物标志物的浓度均显著升高(总Tau，p<；0.0008；p Tau181，p<；0.008)。观察到两种生物标志物的脑脊液浓度之间存在显著的相关性(R=0.897；P<；0.001)。脑脊液中总Tau和pTau181与年龄和记忆损害程度均无相关性，仅观察到脑脊液中总Tau和Abeta42浓度之间的趋势。我们的结果进一步证实了pTau181作为AD诊断工具的可能作用。综述了目前有关磷酸化Tau蛋白的生理和病理作用的文献，以及这些蛋白作为生物标志物在神经退行性疾病诊断中的作用。
Cerebrospinal fluid (CSF) concentrations of total Tau and Tau phosphorylated at threonine (position 181 [pTau181]) were studied with ELISA in a group of carefully selected patients with a neurochemically supported diagnosis of Alzheimer's disease (AD, n = 9; age range, 51-89 yr) and in a group of sex- and age-matched non-demented controls (n = 9; age range, 52-81 yr). The concentration of both biomarkers is increased significantly in the AD group (total Tau, p < 0.0008; pTau181, p < 0.008). A significant correlation between CSF concentrations of both biomarkers is observed (R = 0.897; P < 0.001). Neither total Tau nor pTau181 correlates with age or degree of memory impairment, and only a tendency is observed between the concentrations of total Tau and Abeta42 in the CSF. Our results further confirm a possible role of pTau181 as a diagnostic tool in AD. The current literature regarding the physiological and pathological role of phosphorylated Tau proteins is reviewed, as well as the role of these proteins as promising biomarkers in the diagnosis of neurodegenerative disorders.