Intravenous lidocaine infusion for pain control after laparoscopic cholecystectomy: A meta-analysis of randomized controlled trials.
Intravenous lidocaine infusion for pain control after laparoscopic cholecystectomy: A meta-analysis of randomized controlled trials.
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DOI：
10.1097/md.0000000000009771
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发表时间：
2018-03
期刊：
影响因子：
1.6
通讯作者：
Li FL
中科院分区：
文献类型：
--
作者：
Zhao JB;Li YL;Wang YM;Teng JL;Xia DY;Zhao JS;Li FL
这项荟萃分析旨在评估静脉输注利多卡因用于腹腔镜胆囊切除术（LC）后疼痛管理的有效性和安全性。在 PubMed（1966 年 8 月至 2017 年）、Medline（1966 年 8 月至 2017 年）、Embase（1980 年 8 月至 2017 年）、ScienceDirect（1985 年 8 月至 2017 年）和 Cochrane 图书馆进行了系统检索。仅纳入随机对照试验（RCT）。根据I2统计量检验异质性，采用固定/随机效应模型。使用Stata.11.0软件进行Meta分析。共检索到 5 项随机对照试验，涉及 274 名患者。目前的荟萃分析表明，12小时（加权平均差[WMD]=-0.743，95% CI：-1.246至-0.240，P = .004）、24小时（WMD=-0.712，95% CI：-1.239至-0.184）组间视觉模拟量表评分存在显着差异。 P = .008），LC后48小时（WMD=-0.600，95% CI：-0.972至-0.229，P = .002）。 12 小时（WMD=−3.136，95% CI：−5.591 至−0.680，P = .012）、24 小时（WMD=−4.739，95% CI：−8.291 至−1.188，P = .009）和LC 后 48 小时（WMD=−3.408，95% CI：−5.489 至 −1.326，P = .001）。静脉输注利多卡因可显着降低 LC 术后疼痛评分和阿片类药物消耗量。此外，利多卡因组的不良反应较少。进一步研究仍需要更高质量的随机对照试验。
This meta-analysis aimed to assess the efficiency and safety of intravenous infusion of lidocaine for pain management after laparoscopic cholecystectomy (LC). A systematic search was performed in PubMed (August 1966–2017), Medline (August 1966–2017), Embase (August 1980–2017), ScienceDirect (August 1985–2017), and the Cochrane Library. Only randomized controlled trials (RCTs) were included. Fixed/random effect model was used according to the heterogeneity tested by I2 statistic. Meta-analysis was performed using Stata.11.0 software. A total of 5 RCTs were retrieved involving 274 patients. The present meta-analysis indicated that there were significant differences between groups in terms of visual analog scale scores at 12hours (weighted mean difference [WMD]=−0.743, 95% CI: −1.246 to −0.240, P = .004), 24hours (WMD=−0.712, 95% CI: −1.239 to −0.184, P = .008), and 48hours (WMD=−0.600, 95% CI: −0.972 to −0.229, P = .002) after LC. Significant differences were found regarding opioid consumption at 12hours (WMD=−3.136, 95% CI: −5.591 to −0.680, P = .012), 24hours (WMD=−4.739, 95% CI: −8.291 to −1.188, P = .009), and 48hours (WMD=−3.408, 95% CI: −5.489 to −1.326, P = .001) after LC. Intravenous lidocaine infusion significantly reduced postoperative pain scores and opioid consumption after LC. In addition, there were fewer adverse effects in the lidocaine groups. Higher quality RCTs are still required for further research.