HYPERCALCEMIA IN AN ANEPHRIC PATIENT WITH SARCOIDOSIS - EVIDENCE FOR EXTRA-RENAL GENERATION OF 1,25-DIHYDROXYVITAMIN-D
HYPERCALCEMIA IN AN ANEPHRIC PATIENT WITH SARCOIDOSIS - EVIDENCE FOR EXTRA-RENAL GENERATION OF 1,25-DIHYDROXYVITAMIN-D
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DOI：
10.1056/nejm198108203050807
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发表时间：
1981-01-01
影响因子：
158.5
通讯作者：
HORST, RL
中科院分区：
文献类型：
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作者：
BARBOUR, GL;COBURN, JW;HORST, RL
高达10%的结节病患者可发生高钙血症。1，2在疾病的活动期，肠道对钙的吸收增加导致高钙尿症和偶尔的高钙血症。钙的吸收增加被认为是继发于对维生素D的敏感性增加，3并且它可以通过伴随的肾衰竭的发展而减少或消除。4最近的报告已经确定了1，25-二羟维生素D的循环水平升高（1，25-[OH]2D），并且已经表明这些患者从维生素D产生增加量的1，25-（OH）2D 3。. . .
HYPERCALCEMIA can occur in up to 10 per cent of patients with sarcoidosis.1,2During the active phase of the disease, increased absorption of calcium from the intestine leads to hypercalciuria and occasionally hypercalcemia. The increased absorption of calcium is presumed to be secondary to increased sensitivity to vitamin D,3and it may be decreased or abolished by the development of concomitant renal failure.4Recent reports have identified elevated circulating levels of 1,25-dihydroxyvitamin D (1,25-[OH]2D) in hypercalcemic patients with sarcoidosis, and it has been suggested that such patients produce increased amounts of 1,25-(OH)2D3from vitamin D. . . .