HIGH-RESOLUTION RENAL DIFFUSION IMAGING USING A MODIFIED STEADY-STATE FREE PRECESSION SEQUENCE
HIGH-RESOLUTION RENAL DIFFUSION IMAGING USING A MODIFIED STEADY-STATE FREE PRECESSION SEQUENCE
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DOI：
10.1002/mrm.1910340415
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发表时间：
1995-10-01
影响因子：
3.3
通讯作者：
DUNN, JF
中科院分区：
文献类型：
--
作者：
DING, SJ;TRILLAUD, H;DUNN, JF
本文提出了一种改进的稳态自由旋进（SSFP）扩散序列，用于肾脏高分辨率成像。采用一对双极扩散梯度，以减小先前采用的SSFP扩散序列由于T-1、T-2和RF翻转角的变化而引起的表观扩散系数（ADC）测量误差。采用补偿梯度，降低运动敏感度，逐帧平均和22 ms的重复时间，这对于单次采集128 × 128图像仅需要3 s。通过信号平均获得高分辨率，将改进的序列应用于体内扩散测量。在6只正常大鼠肾脏中，皮质、外髓质和内髓质的ADC（平均值+/-SD; x 10（-3）mm（2）/s）分别为2.28 +/- 0.05、2.38 +/- 0.10和2.95 +/- 0.05。该技术需要相对较大的梯度才能实现足够的扩散加权。
A modified steady-state free precession (SSFP) diffusion sequence is proposed for high resolution renal imaging, A pair of bipolar diffusion gradients was used to minimize the errors in measured apparent diffusion coefficient (ADC) caused by variations in T-1, T-2, and RF flip angle that have been observed with previously employed SSFP diffusion sequences, Motion sensitivity was reduced by the use of compensated gradients, frame-by-frame averaging, and a repetition time of 22 ms, which for a single-acquisition 128 x 128 image requires only 3 s. High resolution was achieved by signal averaging, The modified sequence was applied to in vivo diffusion measurements. In six normal rat kidneys the ADCs (mean+/-SD; x 10(-3) mm(2)/s) of the cortex, outer medulla, and inner medulla were 2.28 +/- 0.05, 2.38 +/- 0.10, and 2.95 +/- 0.05, respectively, The technique requires relatively large gradients to achieve adequate diffusion weighting.