EEG source imaging: Correlating source locations and extents with electrocorticography and surgical resections in epilepsy patients
EEG source imaging: Correlating source locations and extents with electrocorticography and surgical resections in epilepsy patients
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DOI：
10.1097/wnp.0b013e318038fd52
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发表时间：
2007-04-01
影响因子：
2.4
通讯作者：
He, Bin
中科院分区：
文献类型：
--
作者：
Ding, Lei;Wilke, Christopher;He, Bin
利用非侵入性EEG的位置和范围信息来估计致痫灶是理想的。在本研究中，作者使用子空间源定位方法（FINE），结合局部阈值技术，以实现这样的任务。该方法的性能进行了评估，在发作间期的棘波从三个儿科患者的药物难治性部分癫痫。FINE扫描得到的阈值子空间相关性是一个很好的标记，它暗示了与癫痫活动相关的电流源的范围。通过比较发作间期棘波活动的侵入性皮质电图（ECoG）记录结果，验证了研究结果。这三名患者的手术切除与从EEG源和ECoG电位分布确定的致痫区相关性良好。提出的无创技术估计癫痫样活动的价值得到了满意的手术结果的支持。
It is desirable to estimate epileptogenic zones with both location and extent information from noninvasive EEG. In the present study, the authors use a subspace source localization method (FINE), combined with a local thresholding technique, to achieve such tasks. The performance of this method was evaluated in interictal spikes from three pediatric patients with medically intractable partial epilepsy. The thresholded subspace correlation, which is obtained from FINE scanning, is a favorable marker, which implies the extents of current sources associated with epileptic activities. The findings were validated by comparing the results with invasive electrocorticographic (ECoG) recordings of interictal spike activity. The surgical resections in these three patients correlated well with the epileptogenic zones identified from both EEG sources and ECoG potential distributions. The value of the proposed noninvasive technique for estimating epileptiform activity was supported by satisfactory surgery outcomes.