Phonospirometry for noninvasive measurement of ventilation: methodology and preliminary results
Phonospirometry for noninvasive measurement of ventilation: methodology and preliminary results
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DOI：
10.1152/japplphysiol.00028.2002
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发表时间：
2002-10-01
影响因子：
3.3
通讯作者：
Macklem, PT
中科院分区：
文献类型：
--
作者：
Que, CL;Kolmaga, C;Macklem, PT
我们根据气管音测量气管流量，以估计潮气量、每分钟通气量（点I上的（V））、呼吸频率、平均吸气流量（V-T/T-I）和占空比（T-I/T-tot）。在11名正常受试者，3例不稳定的气道阻塞，和3个稳定的哮喘患者，我们测量了气管的声音和流量两次：第一次推导出流量-声音的关系，第二次获得流量-体积的声音信号的关系。将流量-容量关系与呼吸速率导出的容量进行比较。当受试者坐着，面向前方，颈部旋转，屈曲和站立时，流量-容量关系在呼吸速度导出的容量的15%以内。错误随着颈部伸展和仰卧位而增加。然后，我们在安静呼吸期间从气管音中测量通气量，不使用吹口或鼻夹，持续长达30分钟。正常结果+/- SD显示潮气量= 0.37 +/- 0.065升，呼吸频率= 19.3 +/- 3.5次呼吸/分钟，（V）超过点I = 6.9 +/- 1.2 l/min，V-T/T-I = 0.31 +/- 0.06 l/s，T-I/T-tot = 0.37 +/- 0.04。由于V-T/T-I增加，不稳定气道阻塞的V大于点I。除T-I/T-tot外，澄清参数的变化更接近对数正态分布，而不是正态分布，并且在患者中倾向于更大。我们的结论是，在没有喉舌、鼻夹或严格的姿势限制的情况下，语音肺量计测量通气量相当准确。
We measured tracheal flow from tracheal sounds to estimate tidal volume, minute ventilation ((V) over dot I), respiratory frequency, mean inspiratory flow (V-T/T-I), and duty cycle (T-I/T-tot). In 11 normal subjects, 3 patients with unstable airway obstruction, and 3 stable asthmatic patients, we measured tracheal sounds and flow twice: first to derive flow-sound relationships and second to obtain flow-volume relationships from the sound signal. The flow-volume relationship was compared with pneumotach-derived volume. When subjects were seated, facing forward and with neck rotation, flexion, and standing, flow-volume relationship was within 15% of pneumotach-derived volume. Error increased with neck extension and while supine. We then measured ventilation without mouthpiece or nose clip from tracheal sounds during quiet breathing for up to 30 min. Normal results +/- SD revealed tidal volume = 0.37 +/- 0.065 liter, respiratory frequency = 19.3 +/- 3.5 breaths/min, (V) over dot I = 6.9 +/- 1.2 l/min, V-T/T-I = 0.31 +/- 0.06 l/s, and T-I/T-tot 0.37 +/- 0.04. Unstable airway obstruction had large (V) over dot I due to increased V-T/T-I. With the exception of T-I/T-tot, variations in ventilatory parameters were closer to log normal than normal distributions and tended to be greater in patients. We conclude that phonospirometry measures ventilation reasonably accurately without mouthpiece, nose clip, or rigid postural constraints.