Cytosolic BMAL1 moonlights as a translation factor.

Cytosolic BMAL1 moonlights as a translation factor.
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细胞质 BMAL1 兼职作为翻译因子。

DOI:
10.1016/j.tibs.2015.07.006
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发表时间:
2015
影响因子:
13.8
通讯作者:
Partch,CarrieL
Partch,CarrieL
中科院分区:
生物学1区
文献类型:
--
作者:
Michael,AliciaK;Asimgil,Hande;Partch,CarrieL

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人们普遍认为,BMAL1是初级转录因子的一个重要亚单位,它在细胞核内驱动节律性的昼夜转录。令人惊讶的是,Liptonet等人现在表明,BMAL1与胞浆中的翻译机制有节奏地相互作用,以刺激蛋白质合成,以响应mTOR信号。
It is widely recognized that BMAL1 is an essential subunit of the primary transcription factor that drives rhythmic circadian transcription in the nucleus. In a surprising turn, Liptonet al.now show that BMAL1 rhythmically interacts with translational machinery in the cytosol to stimulate protein synthesis in response to mTOR signaling.
DOI: 10.1101/gad.1099503
发表时间: 2003-08-01
影响因子: 10.5
作者:
Kondratov, RV;Chernov, MV;Antoch, MP
通讯作者: Antoch, MP