Ursolic acid loaded-mesoporous bioglass/chitosan porous scaffolds as drug delivery system for bone regeneration
Ursolic acid loaded-mesoporous bioglass/chitosan porous scaffolds as drug delivery system for bone regeneration
复制标题
负载熊果酸的介孔生物玻璃/壳聚糖多孔支架作为骨再生的药物递送系统
DOI：
10.1016/j.nano.2018.10.010
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发表时间：
2019-06-01
影响因子：
5.4
通讯作者：
Zhu, Zhen-An
中科院分区：
文献类型：
--
作者：
Ge, Yu-Wei;Lu, Jia-Wei;Zhu, Zhen-An
生物玻璃支架材料在骨科领域具有巨大的应用潜力，熊果酸（UA）能有效促进体内新骨形成。本文首次开发了负载尿酸的介孔玻璃/壳聚糖多孔支架（MBG/CS/UA），用于促进骨再生。粒径约为300 nm、孔径约为3.9 nm的MBG微球均匀地分散在CS膜上。MBG微球内部的介孔结构以及支架与UA药物之间的氢键作用使MBG/CS/UA支架具有药物控释性能。从支架中释放的UA药物显著增加碱性磷酸酶活性、成骨分化相关基因I型胶原、Runt相关转录因子2表达和成骨细胞相关蛋白表达。此外，微型CT图像、组织形态学观察结果表明，MBG/CS/UA支架提高了新骨形成能力。因此，MBG/CS/UA多孔支架可作为新型骨组织工程材料。(C)2018由Elsevier Inc.出版
Bioglass scaffolds have great application potentials in orthopedics, and Ursolic acid (UA) can effectively promote in vivo new bone formation. Herein, we for the first time developed the mesoporous bioglass/chitosan porous scaffolds loaded with UA (MBG/CS/UA) for enhanced bone regeneration. The MBG microsphcres with particle sizes of similar to 300 nm and pore sizes of similar to 3.9 nm were uniformly dispersed on the CS films. The mesoporous structure within the MBG microspheres and the hydrogen bonding between the scaffolds and UA drugs made the MBG/CS/UA scaffolds have controlled drug release performances. The as-released UA drugs from the scaffolds increased remarkably the alkaline phosphatase activity, osteogenic differentiation related gene type I collagen, runt-related transcription factor 2 expression, and osteoblast-associated protein expression. Moreover, the results of micro-CT images, histomorphological observations demonstrated that the MBG/CS/UA scaffolds improved new bone formation ability. Therefore, the MBG/CS/UA porous scaffolds can be used as novel bone tissue engineering materials. (C) 2018 Published by Elsevier Inc.