Sensory neuropathic cough: A common and treatable cause of chronic cough
Sensory neuropathic cough: A common and treatable cause of chronic cough
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DOI：
10.1016/j.otohns.2006.02.003
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发表时间：
2006-07-01
影响因子：
3.4
通讯作者：
Delsupehe, Kathelijne G.
中科院分区：
文献类型：
--
作者：
Bastian, Robert W.;Vaidya, Abhay M.;Delsupehe, Kathelijne G.
目的：描述我们在第一组患者中治疗慢性感觉神经性咳嗽的经验及其对阿米替林的反应。 研究设计和设置：详细描述了前瞻性患者队列。在之前对咳嗽进行了广泛的阴性检查并且对各种治疗没有反应后，每个人都被转介到所有学术喉科实践。这些患者中的每一位都接受了阿米替林治疗，并要求通过电话访谈的方式定期报告对咳嗽的影响。 结果：第一组连续 12 名患者患有持续 2 个月至 20 年的慢性干咳，且没有（以前）可辨别的原因。提出了纯粹临床的纳入和排除标准。所有患者的自我报告症状均减轻了至少 40%，其中大多数描述短期缓解 75% 至 100%。结论：慢性特发性咳嗽患者可在临床上诊断出感觉神经性咳嗽。尝试使用阿米替林 10 毫克或其他抗神经痛类药物可能会有所帮助。需要进行更长期的对照试验来验证这一实体并证明神经药物治疗慢性感觉神经性咳嗽的疗效。
OBJECTIVE: To describe our experience with chronic sensory neuropathic cough and its response to amitriptyline in a first group of patients.STUDY DESIGN AND SETTING: A prospective cohort of patients is described in detail. Each was referred to all academic laryngological practice after extensive prior negative workup for cough and failure to respond to various treatments. Each of these patients was treated with amitriptyline and asked to report the effect on the Cough at fixed intervals by means of telephone interviews.RESULTS: A first cohort of 12 consecutive patients with a chronic, nonproductive cough that lasted between 2 months and 20 years, with no (formerly) discernible cause is described. Purely clinical criteria of inclusion and exclusion are proposed. All patients had at least 40% reduction of self-reported symptoms, with most describing between 75% to 100% short-term relief.CONCLUSION: Sensory neuropathic Cough can be diagnosed clinically in patients with chronic idiopathic cough. A trial of amitriptyline 10 mg or of other antineuralgia type medications may be helpful. Longer term and controlled trials are warranted to validate this entity and prove efficacy of neurologic medication ill chronic sensory neuropathic cough.