The Cooperative Functions of the EBNA3 Proteins Are Central to EBV Persistence and Latency.
The Cooperative Functions of the EBNA3 Proteins Are Central to EBV Persistence and Latency.
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DOI：
10.3390/pathogens7010031
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发表时间：
2018-03-17
期刊：
影响因子：
--
通讯作者：
Farrell PJ
中科院分区：
文献类型：
--
作者：
Styles CT;Paschos K;White RE;Farrell PJ
Epstein-Barr核抗原3（EBNA 3）蛋白家族，包括EBNA 3A、EBNA 3B和EBNA 3C，在全世界人群中Epstein-Barr病毒（EBV）的无症状持续性和终身潜伏期中起关键作用。EBNA 3介导的许多宿主细胞基因的转录重编程促进体外B细胞转化和体内EB病毒持续存在。尽管结构和序列相似，EBNA 3蛋白之间的大量合作活动的证据，他们执行相当不同，往往相反的功能。EBNA 3A和EBNA 3C都参与重要的肿瘤抑制途径的抑制，并被认为是致癌的。相反，EBNA 3B表现出肿瘤抑制功能。这篇综述着重于EBNA 3蛋白如何实现支持EBV持久性和潜伏期所需的微妙平衡，重点是Allday实验室对EBNA 3生物学领域的贡献。
The Epstein–Barr nuclear antigen 3 (EBNA3) family of proteins, comprising EBNA3A, EBNA3B, and EBNA3C, play pivotal roles in the asymptomatic persistence and life-long latency of Epstein–Barr virus (EBV) in the worldwide human population. EBNA3-mediated transcriptional reprogramming of numerous host cell genes promotes in vitro B cell transformation and EBV persistence in vivo. Despite structural and sequence similarities, and evidence of substantial cooperative activity between the EBNA3 proteins, they perform quite different, often opposing functions. Both EBNA3A and EBNA3C are involved in the repression of important tumour suppressive pathways and are considered oncogenic. In contrast, EBNA3B exhibits tumour suppressive functions. This review focuses on how the EBNA3 proteins achieve the delicate balance required to support EBV persistence and latency, with emphasis on the contribution of the Allday laboratory to the field of EBNA3 biology.
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影响因子：
6.7
作者：
Kalchschmidt JS;Gillman AC;Paschos K;Bazot Q;Kempkes B;Allday MJ
通讯作者：
Allday MJ
影响因子：
6.7
作者：
Banerjee S;Lu J;Cai Q;Sun Z;Jha HC;Robertson ES
通讯作者：
Robertson ES
影响因子：
6.7
作者：
Bazot Q;Paschos K;Skalska L;Kalchschmidt JS;Parker GA;Allday MJ
通讯作者：
Allday MJ
影响因子：
6.7
作者：
Hertle ML;Popp C;Petermann S;Maier S;Kremmer E;Lang R;Mages J;Kempkes B
通讯作者：
Kempkes B
影响因子：
15.3
作者：
Enders, A;Bouillet, P;Puthalakath, H;Xu, YK;Tarlinton, DM;Strasser, A
通讯作者：
Strasser, A