Computational analysis of mechanical stress-strain interaction of a bioresorbable scaffold with blood vessel
Computational analysis of mechanical stress-strain interaction of a bioresorbable scaffold with blood vessel
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DOI：
10.1016/j.jbiomech.2016.05.035
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发表时间：
2016-09-06
影响因子：
2.4
通讯作者：
Zhao, L. G.
中科院分区：
文献类型：
--
作者：
Schiavone, A.;Abunassar, C.;Zhao, L. G.
使用有限元法对生物可吸收聚合物支架Absorb的扩张和展开进行建模，与Co-Cr合金药物洗脱支架Xience V进行直接比较。Absorb支架的扩张率低于Xience V支架，球囊回缩后实现的外径较小。由于设计和材料特性的差异，Absorb也显示出比Xience V更高的回缩，这表明需要额外的后扩张来实现对钙化斑块和僵硬血管患者的有效治疗。然而，Absorb支架对动脉斑块系统的应力显著降低，这在临床上是有益的。偏心斑块引起支架展开的并发症，特别是不均匀的血管扩张。此外，对于偏心率高的斑块，中膜和外膜层中的应力水平也相当高，因此，支架的材料和设计选择至关重要。我们的研究结果表明，在这些情况下，吸收支架的好处被放大。(C)2016爱思唯尔有限公司版权所有
Crimping and deployment of bioresorbable polymeric scaffold, Absorb, were modelled using a finite element method, in direct comparison with Co-Cr alloy drug eluting stent, Xience V. Absorb scaffold has an expansion rate lower than Xience V stent, with a less outer diameter achieved after balloon deflation. Due to the difference in design and material properties, Absorb also shows a higher recoiling than Xience V, which suggests that additional post-dilatation is required to achieve effective treatment for patients with calcified plaques and stiff vessels. However, Absorb scaffold induces significantly lower stresses on the artery-plaque system, which can be clinically beneficial. Eccentric plaque causes complications to stent deployment, especially non-uniform vessel expansion. Also the stress levels in the media and adventitia layers are considerably higher for the plaque with high eccentricity, for which the choice of stents, in terms of materials and designs, will be of paramount importance. Our results imply that the benefits of Absorb scaffolds are amplified in these cases. (C) 2016 Elsevier Ltd. All rights reserved.