The associations between Parkinson's disease and cancer: the plot thickens.
The associations between Parkinson's disease and cancer: the plot thickens.
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DOI：
10.1186/s40035-015-0043-z
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发表时间：
2015
影响因子：
12.6
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Feng DD;Cai W;Chen X
流行病学研究支持癌症发展风险与帕金森病（PD）之间的一般负相关。然而，近年来，越来越多的折衷证据表明，通过不同的时间分析和种族群体，PD与癌症之间存在正相关性。这种正相关性得到了SNCA、PARK2、PARK8、ATM、p53、PTEN和MC1R中几种常见基因突变的支持，这些基因突变导致细胞变化，如线粒体功能障碍、异常蛋白质聚集和细胞周期失调。在这里，我们回顾了过去十年在PD和癌症之间的关联的流行病学和生物学进展，以提供对最近的，有时是相互矛盾的发现的见解。
Epidemiological studies support a general inverse association between the risk of cancer development and Parkinson’s disease (PD). In recent years however, increasing amount of eclectic evidence points to a positive association between PD and cancers through different temporal analyses and ethnic groups. This positive association has been supported by several common genetic mutations in SNCA, PARK2, PARK8, ATM, p53, PTEN, and MC1R resulting in cellular changes such as mitochondrial dysfunction, aberrant protein aggregation, and cell cycle dysregulation. Here, we review the epidemiological and biological advances of the past decade in the association between PD and cancers to offer insight on the recent and sometimes contradictory findings.