Conceptual control across modalities: graded specialisation for pictures and words in inferior frontal and posterior temporal cortex.
Conceptual control across modalities: graded specialisation for pictures and words in inferior frontal and posterior temporal cortex.
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DOI：
10.1016/j.neuropsychologia.2015.02.030
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发表时间：
2015-09
期刊：
影响因子：
2.6
通讯作者：
Jefferies E
中科院分区：
文献类型：
--
作者：
Krieger-Redwood K;Teige C;Davey J;Hymers M;Jefferies E
控制语义提取的话eliminate共同激活下额叶（IFG）和左后颞叶皮层（pMTG），但研究尚未确定（i）这些区域的不同贡献或（ii）是否相同的过程被招募为非言语刺激。单词的含义相对灵活-因此，识别连接两个特定单词的上下文相对要求较高。相比之下，图片是更丰富的刺激，它们的确切含义更好地由它们的可见特征来指定-然而，并非所有这些特征都与揭示给定的关联，挖掘选择/抑制过程有关。为了探索跨模态的潜在差异，我们采取了一种常用的操纵控制检索需求，即识别弱与强关联，并比较了单词和图片版本。有4个关键发现：（1）后IFG（BA 44）中的感兴趣区域（ROI）显示了模态的分级效应（例如，左侧BA 44中的单词>图片;右侧BA 44中的图片>单词）。(2)在不同模态的左侧中间IFG（BA 45）中观察到等效反应，这与通常在LIFG病变后出现的多模态语义控制缺陷一致。(3)前部IFG（BA 47）感兴趣区对言语联想的反应比对图像联想的反应更强，这可能反映了该区域在建立可用于指导语义检索的有意义的上下文方面的作用。(4)左侧pMTG ROI也对跨模态的困难做出了反应，但对言语刺激整体表现出更强的反应，这有助于调和两个不同的文献，这两个文献分别涉及该网站的语义控制和词汇语义访问。我们建议，左前IFG和pMTG一起工作，以保持一个有意义的上下文，形状正在进行的语义处理，这个过程是更强烈的征税字比图片协会。第一个研究语义控制的语言和非语言形式。左中IFG支持单词和图片的受控语义检索。左、右后IFG显示分级的模态效应。左前IFG和pMTG对言语联想的反应比对图片联想的反应更大。这些网站的共同激活可以维持一个上下文来塑造语义处理。
Controlled semantic retrieval to words elicits co-activation of inferior frontal (IFG) and left posterior temporal cortex (pMTG), but research has not yet established (i) the distinct contributions of these regions or (ii) whether the same processes are recruited for non-verbal stimuli. Words have relatively flexible meanings – as a consequence, identifying the context that links two specific words is relatively demanding. In contrast, pictures are richer stimuli and their precise meaning is better specified by their visible features – however, not all of these features will be relevant to uncovering a given association, tapping selection/inhibition processes. To explore potential differences across modalities, we took a commonly-used manipulation of controlled retrieval demands, namely the identification of weak vs. strong associations, and compared word and picture versions. There were 4 key findings: (1) Regions of interest (ROIs) in posterior IFG (BA44) showed graded effects of modality (e.g., words>pictures in left BA44; pictures>words in right BA44). (2) An equivalent response was observed in left mid-IFG (BA45) across modalities, consistent with the multimodal semantic control deficits that typically follow LIFG lesions. (3) The anterior IFG (BA47) ROI showed a stronger response to verbal than pictorial associations, potentially reflecting a role for this region in establishing a meaningful context that can be used to direct semantic retrieval. (4) The left pMTG ROI also responded to difficulty across modalities yet showed a stronger response overall to verbal stimuli, helping to reconcile two distinct literatures that have implicated this site in semantic control and lexical-semantic access respectively. We propose that left anterior IFG and pMTG work together to maintain a meaningful context that shapes ongoing semantic processing, and that this process is more strongly taxed by word than picture associations. One of the first studies of semantic control across verbal and non-verbal modalities. Left mid-IFG supports controlled semantic retrieval for both words and pictures. Left and right posterior IFG show graded modality effects. Left anterior IFG and pMTG respond more to verbal than pictorial associations. Co-activation of these sites may maintain a context to shape semantic processing.