Human cortical networks for new and familiar sequences of saccades
Human cortical networks for new and familiar sequences of saccades
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DOI：
10.1093/cercor/11.10.936
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发表时间：
2001-10-01
期刊：
影响因子：
3.7
通讯作者：
Berthoz, A
中科院分区：
文献类型：
--
作者：
Grosbras, MH;Leonards, U;Berthoz, A
视觉探索是以眼球跳动的序列来组织的，这取决于知觉和认知环境。我们利用功能磁共振成像技术，通过分析新学习和熟悉的眼动序列执行过程中的大脑活动，研究了序列眼动行为的神经基础及其对不同类型记忆的依赖。与静息状态相比，两种类型的序列都激活了一个共同的额顶网络，包括额叶和辅助眼区，以及几个顶区。在这个网络中，新学习的序列比熟悉的序列诱导更强的激活，可能反映了更高的注意要求。此外，根据新序列的表现招募了特定的区域，包括补充前眼野、楔前和尾状核。这表明，除了注意调节外，眼跳序列的新颖性还需要特定的皮质资源，可能与努力序列的准备和协调以及空间工作记忆有关。对于从长期记忆中回忆起来的熟悉序列，我们观察到右侧内侧颞枕激活位于海马旁和舌回之间的边界附近，以及顶枕裂中的一个激活部位。我们得出结论，凝视系统招募的神经元资源可以随着对要执行的扫描路径的熟悉而改变。这项研究对于更好地理解大脑如何执行记忆扫描路径以进行视觉探索和定向非常重要。
Visual exploration is organized in sequences of saccadic eye movements that depend on both perceptual and cognitive context. Using functional magnetic resonance imaging, we studied the neural basis of sequential oculomotor behavior and its dependence on different types of memory by analyzing cerebral activity during performance of newly learned and familiar sequences of eye movements. Compared to a resting condition, both types of sequences activated a common fronto-parietal network, including frontal and supplementary eye fields, and several parietal areas. Within this network, newly learned sequences induced stronger activation than familiar sequences, probably reflecting higher attentional demands. In addition, specific regions were recruited far the performance of new sequences, including pre-supplementary eye fields, the precuneus and the caudate nucleus. This indicates that in addition to attentional modulation, novelty of saccadic sequences requires specific cortical resources, probably related to effortful sequence preparation and coordination as well as to spatial working memory. For familiar sequences, recalled from long-term memory, we observed specific right medial temporo-occipital activation in the vicinity of the boundary between the parahippocampal and lingual gyri, as well as an activation site in the parieto-occipital fissure. We conclude that neuronal resources recruited by the gaze system can change with the familiarity of the scanpath to be executed. This study is important to better understand how the brain implements memorized scanpaths for visual exploration and orienting.