Inter-study reproducibility of cardiovascular magnetic resonance myocardial feature tracking.
Inter-study reproducibility of cardiovascular magnetic resonance myocardial feature tracking.
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DOI：
10.1186/1532-429x-14-43
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发表时间：
2012-06-21
期刊：
影响因子：
--
通讯作者：
Nagel E
中科院分区：
文献类型：
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作者：
Morton G;Schuster A;Jogiya R;Kutty S;Beerbaum P;Nagel E
心血管磁共振心肌特征跟踪（CMR-FT）是最近描述的一种常规电影采集后处理方法，旨在提供周向和径向心室壁应变的定量测量。研究间重现性对于系列评估很重要，但尚未定义CMR-FT。16名健康志愿者在一天内成像3次。第一次检查在空腹后0900进行，随后立即进行第二次检查。第三次，非空腹扫描，在1400进行。计算了CMR-FT测量的节段和整体应变参数。在短轴方向（分别为EccSAX和ErrSAX）测定左心室（LV）周向和径向应变。从4腔方向（分别为EllLV、EllRV和ErrLAX）确定LV和右心室纵向应变以及LV径向应变。还分析了LV容量和功能。通过比较第一次和第二次检查，确定了证明绝对应变变化5%所需的研究间重现性和研究样本量。第三次检查用于确定昼夜变化是否影响再现性。CMR-FT菌株分析的研究间重现性是可变的。整体应变评估比节段性分析更具重现性。总体而言，EccSAX是最具重现性的应变测量：节段性和整体分析的变异系数（CV）分别为38%和20.3%，组内相关系数（ICC）分别为0.68（0.55-0.78）和0.7（0.32-0.89）。最不可重复的节段性测量是EllRV：CV 60%和ICC 0.56（0.41-0.69），而最不可重复的全局性测量是ErrLAX：CV 33.3%和ICC 0.44（0-0.77）。可变的再现性也反映在计算的样本量中，范围从11例（全球EccSAX）到156例受试者（节段性EllRV）。左室容积和功能的再现性极好。整体应变或LV体积测量值无昼夜变化。CMR-FT的研究间重现性在不同参数之间变化，如上所述，并且对于整体分析比节段分析更好。它没有明显的影响，昼夜变化。CMR-FT可能具有定量室壁运动分析的潜力，可应用于患者管理和临床试验。然而，研究间的重现性相对较差的节段和长轴分析的菌株，这还有待验证，并可能受益于进一步的发展。
Cardiovascular magnetic resonance myocardial feature tracking (CMR-FT) is a recently described method of post processing routine cine acquisitions which aims to provide quantitative measurements of circumferentially and radially directed ventricular wall strain. Inter-study reproducibility is important for serial assessments however has not been defined for CMR-FT. 16 healthy volunteers were imaged 3 times within a single day. The first examination was performed at 0900 after fasting and was immediately followed by the second. The third, non-fasting scan, was performed at 1400. CMR-FT measures of segmental and global strain parameters were calculated. Left ventricular (LV) circumferential and radial strain were determined in the short axis orientation (EccSAX and ErrSAX respectively). LV and right ventricular longitudinal strain and LV radial strain were determined from the 4-chamber orientation (EllLV, EllRV, and ErrLAX respectively). LV volumes and function were also analysed. Inter-study reproducibility and study sample sizes required to demonstrate 5% changes in absolute strain were determined by comparison of the first and second exams. The third exam was used to determine whether diurnal variation affected reproducibility. CMR-FT strain analysis inter-study reproducibility was variable. Global strain assessment was more reproducible than segmental analysis. Overall EccSAX was the most reproducible measure of strain: coefficient of variation (CV) 38% and 20.3% and intraclass correlation coefficient (ICC) 0.68 (0.55-0.78) and 0.7 (0.32-0.89) for segmental and global analysis respectively. The least reproducible segmental measure was EllRV: CV 60% and ICC 0.56 (0.41-0.69) whilst the least reproducible global measure was ErrLAX: CV 33.3% and ICC 0.44 (0–0.77). Variable reproducibility was also reflected in the calculated sample sizes, which ranged from 11 (global EccSAX) to 156 subjects (segmental EllRV). The reproducibility of LV volumes and function was excellent. There was no diurnal variation in global strain or LV volumetric measurements. Inter-study reproducibility of CMR-FT varied between different parameters, as summarized above and was better for global rather than segmental analysis. It was not measurably affected by diurnal variation. CMR-FT may have potential for quantitative wall motion analysis with applications in patient management and clinical trials. However, inter-study reproducibility was relatively poor for segmental and long axis analyses of strain, which have yet to be validated, and may benefit from further development.