Inhibition of ErbB receptors, Hedgehog and NF-kappaB signaling by polyphenols in cancer
Inhibition of ErbB receptors, Hedgehog and NF-kappaB signaling by polyphenols in cancer
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DOI：
10.2741/4180
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发表时间：
2013-06-01
影响因子：
3.1
通讯作者：
Bei, Roberto
中科院分区：
文献类型：
--
作者：
Benvenuto, Monica;Fantini, Massimo;Bei, Roberto
癌变是一个多步骤的过程，由累积的基因改变触发，驱动正常细胞向癌细胞的渐进性转化。在信号转导通路中，ErbB受体、核因子-kappaB和Hedgehog(HH)/胶质瘤相关癌基因(GLI)级联通路在肿瘤转化中起重要作用。多酚可用于抑制癌细胞的生长，因为它们能够通过同时直接相互作用或调节基因表达来调节参与致癌的多个靶点的活性。这篇综述将描述ErbB受体、核因子-kappaB和Hedgehog(HH)/胶质瘤相关癌基因(GLI)信号通路之间的相互作用，以及多酚在抑制这种对话和癌细胞生长中的潜在作用。
Carcinogenesis is a multi-step process triggered by cumulative genetic alterations, which drive the progressive transformation of a normal cell into a cancer cell. Among the signal transduction pathways whose crosstalk plays an important role in neoplastic transformation are those mediated by ErbB receptors, NF-kappaB and the Hedgehog (HH)/glioma-associated oncogene (GLI) cascade. Polyphenols can be employed to inhibit the growth of cancer cells due to their ability to modulate the activity of multiple targets involved in carcinogenesis through simultaneous direct interaction or modulation of gene expression. This review will describe the cross-talk between ErbB receptors, NF-kappaB and the Hedgehog (HH)/glioma-associated oncogene (GLI) signaling pathways and the potential role of polyphenols in inhibiting this dialogue and the growth of cancer cells.