Glutathione-S-transferases M1 (GSTM1) and GSTT1 genotype, smoking, consumption of alcohol and tea and risk of esophageal and stomach cancers:: a case-control study of a high-incidence area in Jiangsu Province, China
Glutathione-S-transferases M1 (GSTM1) and GSTT1 genotype, smoking, consumption of alcohol and tea and risk of esophageal and stomach cancers:: a case-control study of a high-incidence area in Jiangsu Province, China
复制标题
DOI：
10.1016/s0304-3835(02)00115-5
复制
发表时间：
2002-12-15
期刊：
影响因子：
9.7
通讯作者：
Tajima, K
中科院分区：
文献类型：
--
作者：
Gao, CM;Takezaki, T;Tajima, K
为探讨生活方式因素与谷胱甘肽S转移酶M1、GSTT1基因之间的相互作用与食管癌、胃癌的关系，对江苏省淮安市食道癌141例、胃癌153例和人群对照223例进行了病例对照研究。采用多重聚合酶链式反应检测GSTM1和GSTT1基因分型。GSTM1缺失基因与食道癌的优势比增加(2.17，95%可信区间=1.35-3.50)有关，但与胃癌无关。吸烟和GSTM1零基因对食道风险的联合作用也被观察到。饮茶是这两种癌症的保护因素，其作用独立于GSTT1和GSTM1基因。这些发现表明，GSTM1基因多态性与食道癌的易感性有关，而喝茶降低了患食道癌和胃癌的风险。(C)2002年，爱思唯尔科学爱尔兰有限公司出版。
To evaluate interactions between lifestyle factors and glutathione-S-transferases M1 (GSTM1) and GSTT1 genotypes with reference to development of esophageal and stomach cancers, we conducted a case-control study of 141 cases of esophageal cancer, 153 cases of stomach cancer and 223 population-based controls in Huaian City of Jiangsu Province, China. GSTM1 and GSTT1 genotypes were identified by multiplex polymerase chain reaction. The GSTM1 null genotype was associated with an increased odds ratio for esophageal cancer (2.17, 95% confidence interval = 1.35-3.50), but not for stomach cancer. A combined effect was also observed between smoking and the GSTM1 null genotype with regard to esophageal risk. Tea drinking was a protective factor for both cancers, its effect being independent of the GSTT1 and GSTM1 genotypes. These findings suggest the GSTM1 polymorphism is involved in the susceptibility to esophageal cancer development, and tea consumption reduces the risk of esophageal and stomach cancers. (C) 2002 Published by Elsevier Science Ireland Ltd.