Mouse models of growth hormone action and aging: a proteomic perspective.
Mouse models of growth hormone action and aging: a proteomic perspective.
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DOI：
10.1002/pmic.201200271
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发表时间：
2013-02
期刊：
影响因子：
3.4
通讯作者：
Kopchick, John J.
中科院分区：
文献类型：
--
作者：
Ding, Juan;Sackmann-Sala, Lucila;Kopchick, John J.
生长激素（GH）是由垂体前叶分泌的蛋白质，在全身循环，对生长和代谢发挥重要作用。GH刺激胰岛素样生长因子-I（IGF-I）的分泌，胰岛素样生长因子-I介导GH的一些生长促进作用。GH/IGF-I轴最近被认为在从C. elegans到mice老鼠例如，GH转基因小鼠寿命短，而GH受体缺失（GHR−/−）小鼠寿命延长。因此，GH（或IGF-I）的作用或缺乏其影响衰老过程。在这篇综述中，我们总结了血浆和白色脂肪组织的蛋白质组学分析在这两个小鼠模型的GH行动，即，GH转基因和GHR−/−小鼠。在蛋白质水平，我们希望建立新的血浆生物标志物的生长激素行动作为年龄的函数，并确定脂肪组织库的差异。我们已经证明，这些蛋白质组学方法不仅证实了GH的几种已知生理作用，而且还产生了新的蛋白质生物标志物和靶标，这些蛋白质生物标志物和靶标可能指示GH的衰老过程和/或新功能。这些结果可能为GH和/或衰老研究产生新的方向。
Growth hormone (GH) is a protein secreted by the anterior pituitary and circulates throughout the body to exert important actions on growth and metabolism. GH stimulates the secretion of insulin-like growth factor-I (IGF-I) which mediates some of the growth promoting actions of GH. The GH/IGF-I axis has recently been recognized as important in terms of longevity in organisms ranging from C. elegans to mice. For example, GH transgenic mice possess short lifespans while GH receptor null (GHR−/−) mice have extended longevity. Thus, the actions of GH (or IGF-I) or lack thereof impacts the aging process. In this review, we summarize the proteomic analyses of plasma and white adipose tissue in these two mouse models of GH action, i.e., GH transgenic and GHR−/− mice. At the protein level, we wanted to establish novel plasma biomarkers of GH action as a function of age and to determine differences in adipose tissue depots. We have shown that these proteomic approaches have not only confirmed several known physiological actions of GH, but also resulted in novel protein biomarkers and targets that may be indicative of the aging process and/or new functions of GH. These results may generate new directions for GH and/or aging research.
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影响因子：
3.7
作者：
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通讯作者：
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