DEVELOPMENT OF THE DOPAMINERGIC INNERVATION IN THE PREFRONTAL CORTEX OF THE RAT
DEVELOPMENT OF THE DOPAMINERGIC INNERVATION IN THE PREFRONTAL CORTEX OF THE RAT
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DOI：
10.1002/cne.902690105
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发表时间：
1988-03-01
影响因子：
2.5
通讯作者：
UYLINGS, HBM
中科院分区：
文献类型：
--
作者：
KALSBEEK, A;VOORN, P;UYLINGS, HBM
从胚胎第14天到出生后第90天，描述了大鼠前额叶皮层（PFC）多巴胺能神经支配的出生前和出生后发育。到胚胎第15天，含多巴胺（DA）的纤维到达外侧新皮层的原基; 2天后，第一批纤维到达未来前额叶皮层的基板。进入皮质板的过程在出生前开始。出生前，在大脑半球的外侧壁和内侧壁的边缘区都可以观察到多巴胺能纤维。出生后48小时内，在边缘区可以观察到大量多巴胺能纤维，即，DA阳性纤维在胚胎晚期和出生后早期出现，特别是在边缘区，可能在膝前扣带皮质的浅层。在P4的DA纤维的形态的变化表明，实际的DA神经支配开始在这个年龄。从出生后第6天开始，根据多巴胺能纤维的地形分布特点，可识别PFC的不同分区。直到出生后第60天，多巴胺能纤维的密度继续增加。出生后60和90天之间的密度和地形没有差异。
The pre- and postnatal development of the dopaminergic innervation in the prefrontal cortex (PFC) of the rat is described from embryonic day 14 through postnatal day 90. By embryonic day 15 the dopamine (DA)-containing fibers reach the anlage of the lateral neocortex; 2 days later the first fibers have reached the subplate of the future prefrontal cortex. The process of entering the cortical plate starts just before birth. Prenatally, some dopaminergic fibers can be observed in the marginal zone of both the lateral and the medial wall of the hemisphere. Within 48 hours after birth a large number of dopaminergic fibres can be observed in the marginal zone, i.e., the future layer I, in some subareas of the PFC. A transient appearance of DA-positive fibers is noticed in the late embryonic and early postnatal periods especially in the marginal zone and possibly in the superficial layers of th pregenual cingulate cortex. Changes in the morphology of DA fibers at P4 suggest that the actual DA innervation starts at this age. From postnatal day 6 the different subareas of the PFC can be recognized according to the characteristics of the topographical distribution of the dopaminergic fibers. Until postnatal day 60 the density of the dopaminergic fibers continues to increase. No difference in density and topography was observed between postnatal days 60 and 90.