Adult rats stressed as neonates show exaggerated behavioral responses to both pharmacological and environmental challenges.
Adult rats stressed as neonates show exaggerated behavioral responses to both pharmacological and environmental challenges.
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成年大鼠受到压力，而新生儿则对药理和环境挑战表现出夸张的行为反应。
DOI：
10.1037//0735-7044.112.1.116
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发表时间：
1998
影响因子：
1.9
通讯作者：
G. Rappolt
中科院分区：
文献类型：
--
作者：
P. Kehoe;W. Shoemaker;L. Triano;M. Callahan;G. Rappolt
研究了从出生后第2天至第9天每天与母亲和巢隔离1小时的成年大鼠。对照组包括处理的同窝仔以及从未处理的单独窝仔。成年后，对动物进行药理学激发（1.0或2.0 mg/kg安非他明）或环境激发（束缚）。在两种药物剂量下，与对照组相比，先前隔离的动物表现出增加的活性。同样，隔离动物在束缚后表现出过度的活动抑制。在基线条件下（注射生理盐水或无束缚），先前隔离的动物与对照组相比通常未显示差异。新生儿经历导致的神经可塑性变化是持久的，并在系统受到挑战时出现。
Adult rats that were isolated from the mother and nest for 1 hr per day from Postnatal Day 2 to 9 were studied. Controls consisted of handled littermates as well as separate litters that were never handled. As adults, animals were given either a pharmacological challenge (1.0 or 2.0 mg/kg amphetamine) or an environmental challenge (restraint). Previously isolated animals demonstrated increased activity compared to controls at both drug doses. Similarly, isolated animals manifested exaggerated inhibition of activity after restraint. Previously isolated animals usually did not show differences compared to controls under baseline conditions (saline injection or no restraint). The neuroplastic changes that result from the neonatal experience are long lasting and appear when the system is challenged.