Fukushima simulation experiment: assessing the effects of chronic low-dose-rate internal 137Cs radiation exposure on litter size, sex ratio, and biokinetics in mice.
Fukushima simulation experiment: assessing the effects of chronic low-dose-rate internal 137Cs radiation exposure on litter size, sex ratio, and biokinetics in mice.
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DOI：
10.1093/jrr/rrv079
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发表时间：
2015-12
影响因子：
2
通讯作者：
Todo T
中科院分区：
文献类型：
--
作者：
Nakajima H;Yamaguchi Y;Yoshimura T;Fukumoto M;Todo T
为了研究日本福岛第一核电站事故后慢性低剂量率内辐射暴露的跨代效应，研究人员将18代小鼠置于放射性同位素设施中，让它们免费饮用含有137CsCl（0和100 Bq/ml）的饮用水。长期随意饮用137CsCl水后，测定小鼠各脏器中137Cs的分布。将饮用137Cs水的18代小鼠的产仔数和性别比例与对照组进行比较。对照组和饮用137Cs水的小鼠在产仔数和性别比上没有显著差异。肌肉和其他器官的固定内暴露剂量分别为~ 160 Bq/g和80 Bq/g。
To investigate the transgenerational effects of chronic low-dose-rate internal radiation exposure after the Fukushima Daiichi Nuclear Power Plant accident in Japan, 18 generations of mice were maintained in a radioisotope facility, with free access to drinking water containing 137CsCl (0 and 100 Bq/ml). The 137Cs distribution in the organs of the mice was measured after long-term ad libitum intake of the 137CsCl water. The litter size and the sex ratio of the group ingesting the 137Cs water were compared with those of the control group, for all 18 generations of mice. No significant difference was noted in the litter size or the sex ratio between the mice in the control group and those in the group ingesting the 137Cs water. The fixed internal exposure doses were ∼160 Bq/g and 80 Bq/g in the muscles and other organs, respectively.