Macrophages: micromanagers of antagonistic signaling nanoclusters.
Macrophages: micromanagers of antagonistic signaling nanoclusters.
复制标题
DOI：
10.1083/jcb.201702028
复制
发表时间：
2017-04-03
期刊：
影响因子：
--
通讯作者：
Davis SJ
中科院分区：
文献类型：
--
作者：
Eggeling C;Davis SJ
Eggeling和Davis讨论了Lopes等人的工作，展示了巨噬细胞如何通过受体重组整合拮抗信号事件。细胞如何整合拮抗性受体信号事件是个谜。使用超分辨率光学显微镜，Lopes et al.（2017. 201608094）证明了巨噬细胞中拮抗性信号传导受体在被活化和抑制性配体的受体接合后的纳米级分子重组。他们提出，这种类型的大规模重组支持这些细胞的决策。
Eggeling and Davis discuss work by Lopes et al. demonstrating how macrophages integrate antagonistic signaling events via receptor reorganization. How cells integrate antagonistic receptor signaling events is enigmatic. Using superresolution optical microscopy, Lopes et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608094) demonstrate the nanometer-scale molecular reorganization of antagonistic signaling receptors in macrophages, after engagement by the receptors of activating and inhibitory ligands. They propose that large-scale rearrangements of this type underpin decision-making by these cells.