NEW DIMENSIONS IN NATURAL-PRODUCTS RESEARCH - CULTURED MARINE MICROORGANISMS
NEW DIMENSIONS IN NATURAL-PRODUCTS RESEARCH - CULTURED MARINE MICROORGANISMS
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DOI：
10.1016/0958-1669(95)80049-2
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发表时间：
1995-06-01
影响因子：
7.7
通讯作者：
DAVIDSON, BS
中科院分区：
文献类型：
--
作者：
DAVIDSON, BS
经过近40年的研究，发现了6000多种新化合物，海洋天然产物研究人员开始从不同的角度看待海洋环境。海洋微生物，包括细菌，真菌和微藻，其中大多数以前被忽视，现在已经成为生物活性化合物的重要新来源。令人兴奋的最近的结果包括具有里程碑意义的结构特征的maitotoxin，甲藻代谢物，是有史以来最毒和最大的非生物聚合物的研究，并发现curacin A，一个潜在的抗癌剂从海洋蓝藻。虽然新的化合物正在从海洋微生物中分离出来，但仍然非常需要开发微生物学方法，以便能够分离和培养真正为海洋环境所独有的微生物。
After almost 40 years of investigation, a period in which over 6000 new compounds have been discovered, marine natural products researchers have begun to view the marine environment from a different perspective. Marine microorganisms, including bacteria, fungi, and microalgae, most of which were previously ignored, have now come into focus as important new sources of biologically active compounds. Exciting recent results include the landmark structural characterization of maitotoxin, a dinoflagellate metabolite that is the most toxic and largest non-biopolymer ever studied, and the discovery of curacin A, a potential anticancer agent from a marine cyanobacterium. Although new compounds are being isolated from marine microorganisms, a great need exists for the development of microbiological methods that will allow the isolation and culture of microorganisms that are truly unique to the marine environment.