Associations of prenatal heavy metals exposure with placental characteristics and birth weight in Hangzhou Birth Cohort: Multi-pollutant models based on elastic net regression
Associations of prenatal heavy metals exposure with placental characteristics and birth weight in Hangzhou Birth Cohort: Multi-pollutant models based on elastic net regression
复制标题
杭州出生队列产前重金属暴露与胎盘特征和出生体重的关系：基于弹性网络回归的多污染物模型
DOI：
10.1016/j.scitotenv.2020.140613
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发表时间：
2020-11-10
影响因子：
9.8
通讯作者：
Chen，Guangdi
中科院分区：
文献类型：
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作者：
Zhao，Hao;Tang，Jun;Chen，Guangdi
背景人类胎盘易受环境污染物的影响，但暴露于多种相关金属与胎盘特征之间的关系尚未研究过。在妊娠20-28周期间从母亲收集全血和尿液样品。采用电感耦合等离子体质谱法测定了血液和尿液中11种金属的浓度。胎盘特征和出生体重的数据来自医疗记录。采用弹性网络模型结合非惩罚回归模型估计金属水平与胎盘特征（胎盘重量、绒毛膜盘面积、绒毛膜盘偏心率、胎盘厚度、胎盘-胎儿出生体重比）和出生体重的关系。中介分析，探讨胎盘的介导作用，产前金属接触与出生weight.ResultsAmong 512参与者与尿金属水平，ENET模型保留镉（Cd）和硒（Se）胎盘重量。进一步的非惩罚回归模型同时包括镉和硒，结果显示，自然对数（ln）转换的尿肌酐校正（CC）镉水平增加一个单位与胎盘重量减少−7.2 g相关（95%置信区间（CI）：−14.0，−0.4）。同样，在483名血液金属水平的参与者中，血液镉水平与胎盘重量呈负相关（β = −7.5，95%CI：−17.0，1.9）。此外，中介分析表明，尿CC-Cd水平与21.3g下降相关（95%置信区间：−42.0，− 2.5，p = 0.024），通过降低胎盘重量，结论胎盘在产前镉暴露与低出生率的关系中起着中介作用重量.需要进行额外的研究，重复评估暴露量和更多胎盘参数，以证实这种关系。
BackgroundThe human placenta is vulnerable to environmental pollutants, but the associations between exposure to multiple, correlated metals and placental characteristics have not been studied.MethodsThe current study population was derived from the Hangzhou Birth Cohort Study. Whole blood and urine samples were collected from mothers during 20–28 gestational week. The concentrations of 11 metals in blood and 11 metals in urine were evaluated by inductively coupled plasma mass spectrometry. The data on placental characteristics and birth weight were retrieved from medical records. The elastic net (ENET) model combined with unpenalized regression model was employed to estimate the relationship between levels of metals and placental characteristics (placental weight, chorionic disc area, chorionic disc eccentricity, placental thickness, placental-fetal birth weight ratio) and birth weight. Mediation analysis was performed to explore the mediated effect of placenta on the association of prenatal metals exposure with birth weight.ResultsAmong 512 participants with urine metal levels, the ENET model retained Cadmium (Cd) and Selenium (Se) for placental weight. Further unpenalized regression model including Cd and Se simultaneously showed that one-unite increased natural-logarithm (ln)-transformed urine creatinine corrected (CC) Cd levels was associated with reductions in placental weight of −7.2 g (95% confidence interval (CI): −14.0, −0.4). Among 483 participants with blood metal levels, similarly, blood Cd levels were negatively associated with placental weight (β = −7.5, 95% CI: −17.0, 1.9). Furthermore, mediation analysis demonstrated that urine CC-Cd level was associated with a 21.3 g decrease (95% CI: −42.0, −2.5,p= 0.024) in birth weight through a reduction in placental weight, while blood Cd levels presented a negative association at borderline significance.ConclusionOur findings suggest a mediation effect of the placenta in the relationship between prenatal Cd exposure and lower birth weight. Additional studies with repeated assessment of exposure and more placental parameters are warranted to confirm this relationship.