A radical signal activates the epigenetic regulation of longevity.
A radical signal activates the epigenetic regulation of longevity.
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DOI：
10.1016/j.cmet.2013.05.015
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发表时间：
2013-06
期刊：
影响因子：
29
通讯作者：
M. Mirisola;V. Longo
中科院分区：
文献类型：
--
作者：
M. Mirisola;V. Longo
毒物兴奋效应是一种与寿命调节有关的适应性应激反应。施罗德等人。 (2013) 现在通过证明线粒体衍生的活性氧调节亚端粒处组蛋白去甲基酶 Rph1p 的染色质结合能力，从而将酵母的压力、表观遗传变化和衰老联系起来，从而延长寿命。
Hormesis is an adaptive stress response implicated in longevity regulation. Schroeder et al. (2013) have now connected stress, epigenetic changes, and aging in yeast by showing that mitochondria-derived reactive oxygen species modulate the chromatin binding capacity of the histone demethylase Rph1p at subtelomeres, resulting in lifespan extension.