Dietary intake of stearidonic acid-enriched soybean oil increases the omega-3 index: randomized, double-blind clinical study of efficacy and safety
Dietary intake of stearidonic acid-enriched soybean oil increases the omega-3 index: randomized, double-blind clinical study of efficacy and safety
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DOI：
10.3945/ajcn.2009.29072
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发表时间：
2010-10-01
影响因子：
7.1
通讯作者：
Harris, William S.
中科院分区：
文献类型：
--
作者：
Lemke, Shawna L.;Vicini, John L.;Harris, William S.
背景：omega-3（n-3）长链多不饱和脂肪酸对心脏健康的益处已得到充分证实。十八碳四烯酸目的：目的是评估含SDA的大豆油与EPA和常规大豆油（对照）相比增加omega-3指数[红细胞二十碳五烯酸（EPA）+二十二碳六烯酸，作为总脂肪酸的百分比]和影响其他心血管疾病风险标志物的能力。设计：这是一项随机、安慰剂对照、双盲、多中心研究，252例超重受试者被随机分配至3种治疗之一，持续12周：1 g胶囊化大豆油/天加14.7 g液体大豆油/天，混入食物中（对照组）、1g包封EPA/d +14.7g液体大豆油/d（EPA组）和1g包封大豆油/d +14.7g富含SDA的液体大豆油/d，提供4.2g SDA（SDA组）。受试者消耗的治疗油，以换取其他油在他们的diet.Results：治疗之间的平均（+/- SE）基线欧米茄-3指数是相似的，但在12周的治疗值为这个指数分别为4.15 +/-0.12%，4.84 +/-0.13%，和4.69 +/- 0.15%的控制，EPA和SDA组，分别。在意向治疗人群中，EPA和SDA组的数值大于对照组（分别为P < 0.001和P = 0.006）。没有不良的治疗相关的影响SDA富集大豆油reported.Conclusions：SDA富集大豆油增加欧米茄-3指数，提高红细胞EPA浓度。富含SDA的大豆油是一种陆基n-3脂肪酸，是增加长链多不饱和n-3脂肪酸组织浓度的可持续方法。美国临床营养杂志2010;92：766-75。
Background: The benefits of omega-3 (n-3) long-chain polyunsaturated fatty acids to heart health are well established. Stearidonic acid (SDA, 18:4n-3) may contribute to these benefits.Objective: The objective was to evaluate the ability of SDA-containing soybean oil to increase the omega-3 index [erythrocyte eicosapentaenoic acid (EPA) + docosahexaenoic acid, as a percentage of total fatty acids] and to affect other cardiovascular disease risk markers compared with EPA and regular soy oil (control).Design: This was a randomized, placebo-controlled, double-blind multicenter study in which 252 overweight subjects were randomly assigned to 1 of 3 treatments for 12 wk: 1 g encapsulated soybean oil/d plus 14.7 g liquid soybean oil/d to be mixed in food (control group), 1 g encapsulated EPA/d plus 14.7 g liquid soybean oil/d (EPA group), and 1 g encapsulated soybean oil/d plus 14.7 g liquid SDA-enriched soybean oil/d, providing 4.2 g SDA (SDA group). Subjects consumed treatment oils in exchange for other oils in their diet.Results: The mean (+/- SE) baseline omega-3 index was similar between treatments, but after 12 wk of treatment values for this index were 4.15 +/- 0.12%, 4.84 +/- 0.13%, and 4.69 +/- 0.15% for control, EPA, and SDA groups, respectively. Values for the EPA and SDA groups were greater than those for control subjects in the intent-to-treat population (P < 0.001 and P = 0.006, respectively). No adverse treatment-related effects of SDA-enriched soybean oil were reported.Conclusions: SDA-enriched soybean oil increased the omega-3 index by raising erythrocyte EPA concentrations. SDA-enriched soybean oil is a land-based n-3 fatty acid that is a sustainable approach to increasing tissue concentrations of long-chain polyunsaturated n-3 fatty acids. Am J Clin Nutr 2010;92:766-75.