Uncommon GNAQ, MMP8, AKT3, EGFR, and PIK3R1 mutations in thyroid cancers.
Uncommon GNAQ, MMP8, AKT3, EGFR, and PIK3R1 mutations in thyroid cancers.
复制标题
DOI：
10.1007/s12022-011-9155-x
复制
发表时间：
2011-06
影响因子：
4.4
通讯作者：
Xing M
中科院分区：
文献类型：
--
作者：
Murugan AK;Dong J;Xie J;Xing M
Frequent mutations in the GNAQ, MMP8, Akt3, EGFR, and PIK3R1 genes have been reported in human cancers but mostly have not been well examined in thyroid cancer. Selected exons of GNAQ, MMP8, AKT3, EGFR, and PIK3R1 genes were sequenced in various thyroid cancers. We found a G2203A EGFR mutation, resulting in a G735S amino acid change, in one of 21 (5%) papillary thyroid cancer samples. We did not find any mutation in the MMP8 gene, but observed a frequent SNP A259G (K87E) genotype switch in various types of thyroid cancer samples. We did not find any mutation in the GNAQ, AKT3, and PIK3R1genes in various types of thyroid cancer. No mutation in these genes was found in 12 cell lines derived from various types of thyroid cancer. Therefore, unlike in other cancers, mutations in these genes are uncommon in thyroid cancer.
登录
查看更多内容
影响因子：
8.8
作者：
Davies, M. A.;Stemke-Hale, K.;Tellez, C.;Calderone, T. L.;Deng, W.;Prieto, V. G.;Lazar, A. J. F.;Gershenwald, J. E.;Mills, G. B.
通讯作者：
Mills, G. B.
影响因子：
3.7
作者：
Lamba S;Felicioni L;Buttitta F;Bleeker FE;Malatesta S;Corbo V;Scarpa A;Rodolfo M;Knowles M;Frattini M;Marchetti A;Bardelli A
通讯作者：
Bardelli A
影响因子：
5.8
作者：
Liu, Zhi;Hou, Peng;Xing, Mingzhao
通讯作者：
Xing, Mingzhao
影响因子：
11.2
作者：
Nagai, Y;Miyazawa, H;Hagiwara, K
通讯作者：
Hagiwara, K
影响因子：
5.8
作者：
Mitsiades, Constantine S.;Kotoula, Vassiliki;Mitsiades, Nicholas
通讯作者：
Mitsiades, Nicholas