Salivary defense proteins: their network and role in innate and acquired oral immunity.
Salivary defense proteins: their network and role in innate and acquired oral immunity.
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DOI：
10.3390/ijms13044295
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发表时间：
2012
影响因子：
5.6
通讯作者：
Fábián G
中科院分区：
文献类型：
--
作者：
Fábián TK;Hermann P;Beck A;Fejérdy P;Fábián G
唾液中有许多防御蛋白。虽然这些分子中的一些以相当低的浓度存在，但它们的作用是累加的和/或协同的，导致口腔的有效分子防御网络。此外，这些蛋白质在粘膜表面（粘膜渗出液）、牙周沟（龈沟液）和口腔伤口和溃疡（渗出液）附近的局部浓度可能更高，并且在许多情况下通过口腔粘膜的免疫和/或炎症反应而增强。一些防御蛋白，如唾液免疫球蛋白和唾液伴侣蛋白HSP 70/HSPAs（70 kDa热休克蛋白），参与先天性和获得性免疫。阳离子肽和其他防御蛋白如溶菌酶、杀菌/通透性增加蛋白（BPI）、BPI样蛋白、PLYP（腭肺和鼻上皮克隆）蛋白、唾液淀粉酶、半胱氨酸蛋白酶抑制剂、富含脯氨酸的蛋白、粘蛋白、过氧化物酶、唾液酸抑制蛋白等主要负责先天免疫。本文就唾液防御蛋白的复杂系统及其功能作一综述。
There are numerous defense proteins present in the saliva. Although some of these molecules are present in rather low concentrations, their effects are additive and/or synergistic, resulting in an efficient molecular defense network of the oral cavity. Moreover, local concentrations of these proteins near the mucosal surfaces (mucosal transudate), periodontal sulcus (gingival crevicular fluid) and oral wounds and ulcers (transudate) may be much greater, and in many cases reinforced by immune and/or inflammatory reactions of the oral mucosa. Some defense proteins, like salivary immunoglobulins and salivary chaperokine HSP70/HSPAs (70 kDa heat shock proteins), are involved in both innate and acquired immunity. Cationic peptides and other defense proteins like lysozyme, bactericidal/permeability increasing protein (BPI), BPI-like proteins, PLUNC (palate lung and nasal epithelial clone) proteins, salivary amylase, cystatins, prolin-rich proteins, mucins, peroxidases, statherin and others are primarily responsible for innate immunity. In this paper, this complex system and function of the salivary defense proteins will be reviewed.
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