Mendelian Randomization Analysis Reveals No Causal Relationship Between Nonalcoholic Fatty Liver Disease and Severe COVID-19.
Mendelian Randomization Analysis Reveals No Causal Relationship Between Nonalcoholic Fatty Liver Disease and Severe COVID-19.
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DOI：
10.1016/j.cgh.2022.01.045
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发表时间：
2022-07
期刊：
影响因子：
--
通讯作者：
Chen P
中科院分区：
文献类型：
--
作者：
Li J;Tian A;Zhu H;Chen L;Wen J;Liu W;Chen P
截至撰写本文时，2019冠状病毒病（COVID-19）大流行已导致超过450万人死亡。非酒精性脂肪性肝病（NAFLD）是否会增加严重COVID-19的风险仍不清楚。我们试图解决这个问题，使用2样本孟德尔随机化（TSMR）分析方法在大的队列。我们进行了大规模TSMR分析，以检查NAFLD、血清丙氨酸氨基转移酶、脂肪变性分级、NAFLD活动评分或纤维化分期与严重COVID-19之间是否存在因果关系。为了最大限度地提高该分析的效力，我们进行了全基因组荟萃分析，以确定与NAFLD相关的单核苷酸多态性。我们还研究了NAFLD的20个主要共病因素对严重COVID-19的影响。英国生物银行数据的单变量分析显示，NAFLD与严重COVID-19之间存在显著相关性（比值比[OR]，3.06; P = 1.07 × 10-6）。然而，在调整人口统计学和共病因素后，这种关联消失（OR，1.57; P = 0.09）。TSMR研究表明，NAFLD（OR，0.97; P = 0.61）、丙氨酸氨基转移酶水平（OR，1.03; P = 0.47）、脂肪变性分级（OR，1.08; P = 0.41）、NAFLD活动评分（OR，1.02; P = 0.39）和纤维化分期（OR，1.01; P = 0.87）与重度COVID-19无关。在所有NAFLD相关共病因素中，体重指数（OR，1.73; P = 7.65 × 10-9）、腰围（OR，1.76; P = 2.58 × 10-5）和臀围（OR，1.33; P = 7.26 × 10-3）是唯一对严重COVID-19有因果影响的因素。没有证据支持NAFLD是严重COVID-19的因果风险因素。先前观察到的NAFLD和COVID-19之间的关联可能归因于NAFLD和肥胖之间的相关性。
The coronavirus disease 2019 (COVID-19) pandemic has witnessed more than 4.5 million deaths as of the time of writing. Whether nonalcoholic fatty liver disease (NAFLD) increases the risk for severe COVID-19 remains unclear. We sought to address this question using 2-sample Mendelian randomization (TSMR) analysis approaches in large cohorts. We performed large-scale TSMR analyses to examine whether there is a causal relationship between NAFLD, serum alanine aminotransferase, grade of steatosis, NAFLD Activity Score, or fibrosis stage and severe COVID-19. To maximize the power of this analysis, we performed a genome-wide meta-analysis to identify single nucleotide polymorphisms associated with NAFLD. We also examined the impact of 20 major comorbid factors of NAFLD on severe COVID-19. Univariate analysis of the UK Biobank data demonstrated a significant association between NAFLD and severe COVID-19 (odds ratio [OR], 3.06; P = 1.07 × 10–6). However, this association disappeared after demographic and comorbid factors were adjusted (OR, 1.57; P = .09). TSMR study indicated that NAFLD (OR, 0.97; P = .61), alanine aminotransferase level (OR, 1.03; P = .47), grade of steatosis (OR, 1.08; P = .41), NAFLD Activity Score (OR, 1.02; P = .39), and fibrosis stage (OR, 1.01; P = .87) were not associated with severe COVID-19. Among all NAFLD-related comorbid factors, body mass index (OR, 1.73; P = 7.65 × 10–9), waist circumference (OR, 1.76; P = 2.58 × 10–5), and hip circumference (OR, 1.33; P = 7.26 × 10–3) were the only ones demonstrated a causal impact on severe COVID-19. There is no evidence supporting that NAFLD is a causal risk factor for severe COVID-19. Previous observational associations between NAFLD and COVID-19 are likely attributed to the correlation between NAFLD and obesity.
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影响因子：
7.7
作者：
Bowden J;Del Greco M F;Minelli C;Davey Smith G;Sheehan NA;Thompson JR
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影响因子：
7.7
作者：
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Lawlor DA
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y