T Cells in Fish.
T Cells in Fish.
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DOI：
10.3390/biology4040640
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发表时间：
2015-09-25
期刊：
影响因子：
4.2
通讯作者：
Matsuura Y
中科院分区：
文献类型：
--
作者：
Nakanishi T;Shibasaki Y;Matsuura Y
软骨鱼是最原始的有胸腺的脊椎动物，拥有与哺乳动物相同的T细胞。在FISH中有许多研究表明，胸腺是T淋巴细胞从早期胸腺细胞前体细胞发育为具有功能的T细胞所必需的器官。据报道，在几种鱼类的肠道和鳃中存在大量的T细胞。CD_4~+和CD_8~+α~+T细胞参与同种异体移植排斥反应和移植物抗宿主反应。利用混合白细胞培养(MLC)和半抗原/载体效应的一些研究表明，硬骨鱼中的CD4+辅助T细胞功能是保守的。同种异体抗原和病毒特异性的细胞毒性在金鱼和虹鱼中也被证明。此外，据报道，细胞免疫而不是体液免疫在预防细胞内细菌感染方面发挥了重要作用。近年来，CD8CD4+、α+T细胞和SIGM+细胞在FISH中的直接抗菌活性已有报道。本文就鱼类T细胞的组织分布和功能等方面的研究进展作一综述。
Cartilaginous and bony fish are the most primitive vertebrates with a thymus, and possess T cells equivalent to those in mammals. There are a number of studies in fish demonstrating that the thymus is the essential organ for development of T lymphocytes from early thymocyte progenitors to functionally competent T cells. A high number of T cells in the intestine and gills has been reported in several fish species. Involvement of CD4+ and CD8α+ T cells in allograft rejection and graft-versus-host reaction (GVHR) has been demonstrated using monoclonal antibodies. Conservation of CD4+ helper T cell functions among teleost fishes has been suggested in a number studies employing mixed leukocyte culture (MLC) and hapten/carrier effect. Alloantigen- and virus-specific cytotoxicity has also been demonstrated in ginbuna and rainbow trout. Furthermore, the important role of cell-mediated immunity rather than humoral immunity has been reported in the protection against intracellular bacterial infection. Recently, the direct antibacterial activity of CD8α+, CD4+ T-cells and sIgM+ cells in fish has been reported. In this review, we summarize the recent progress in T cell research focusing on the tissue distribution and function of fish T cells.