Repetitive transcranial magnetic stimulation in the treatment of depression in adolescents: An open-label study
Repetitive transcranial magnetic stimulation in the treatment of depression in adolescents: An open-label study
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DOI：
10.1097/yct.0b013e318156aa49
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发表时间：
2008-06-01
期刊：
影响因子：
2.5
通讯作者：
Levkovitz, Yechiel
中科院分区：
文献类型：
--
作者：
Bloch, Yarval;Grisaru, Nimrod;Levkovitz, Yechiel
目的：这项开放标签的初步研究探讨了重复经颅磁刺激作为一种可能的治疗青少年难治性抑郁症。9名青少年（16-18岁）患有严重顽固性抑郁症（由SCID确定），并在20次10 Hz治疗前、治疗中和治疗后评估他们的抑郁、自杀倾向和认知功能，2秒列车结果：Beck抑郁量表和儿童抑郁评定量表测量均记录了治疗进展的较低水平的抑郁症（F-1.7，F-14.01 = 4.52，P < 0.05; F-4，F-32 = 6.645，P < 0.01）。3名患者达到了儿童抑郁量表降低30%以下的主要结局指标。对自杀倾向的影响不显著。结论：重复经颅磁刺激可能是治疗青少年抑郁症的一种可能的方法。我们的初步研究结果保证了双盲对照研究。
Objective: This open-label pilot study examined repetitive transcranial magnetic stimulation as a possible treatment of adolescent resistant depression.Method: Nine adolescents (aged 16-18 years) with severe resistant depression (determined by SCID) were recruited, and their depression, suicidality, and cognitive functions were evaluated before, during, and after a course of twenty 10-Hz, 2-second trains (intertrain intervals of 58 seconds) given over 20 min/d over 14 working days.Results: Lower levels of depression with progression in therapy were recorded by both the Beck Depression Inventory and Child Depression Rating Scale measures (F-1.7,F-14.01 = 4.52, P < 0.05; F-4,F-32 = 6.645, P < 0.01, respectively). Three patients reached the primary outcome measure of less than 30% reduction in their Child Depression Rating Scale. The effect on suicidality was not significant. Side effects were considered mild.Conclusions: Repetitive transcranial magnetic stimulation might be a possible therapy for adolescent depression. Our preliminary findings warrant double-blind, controlled studies.