The change of fetal heart rate short-term variability during the course of histological chorioamnionitis in fetal sheep
The change of fetal heart rate short-term variability during the course of histological chorioamnionitis in fetal sheep
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DOI：
10.1016/j.ejogrb.2018.06.015
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发表时间：
2018-09-01
影响因子：
2.6
通讯作者：
Fujimori, Keiya
中科院分区：
文献类型：
--
作者：
Kyozuka, Hyo;Yasuda, Syun;Fujimori, Keiya
目的：组织学绒毛膜炎（CAM）与新生儿死亡率和发病率有关。然而，在分娩前识别子宫内炎症具有挑战性。本研究的目的是探讨胎心率（FHR）的短期变异性（STV）的变化过程中的组织学CAM。研究设计：STV的变化进行了测量，在7个长期仪表胎羊在妊娠111-120天。术后第4天，向羊膜腔内注入脂多糖（LPS）2天，以形成组织学CAM。STV是根据胎儿心电图的R到R间期确定的。连续观察STV的变化，直至胎儿宫内死亡（IUFD）。IUFD后对脐带和胎膜进行组织学评价。实验分为两个阶段：1）急性期，定义为第一次和第二次注射LPS之间的24小时时间段; 2）围死亡期，定义为第二次注射LPS和IUFD之间的时间段。使用Friedman检验评价急性期和围死期STV的变化。的概率
Objective: Histological chorioamnionitis (CAM) is related to neonatal mortality and morbidity. However, identifying intrauterine inflammation before delivery is challenging. The aim of this study was to investigate the changes in fetal heart rate (FHR) short-term variability (STV) during the course of histological CAM.Study Design: Changes in STV were measured in 7 chronically instrumented fetal sheep at 111-120 days of gestation. Lipopolysaccharide (LPS) was infused into the amniotic cavity for 2 days following the 4th postoperative day to develop histological CAM. STV was determined based on the R to R interval of the fetal electrocardiogram. We continued to observe the changes in STV until the time of intrauterine fetal death (IUFD). The umbilical cord and fetal membranes were evaluated histologically after IUFD. The experiment was divided into two phases: 1) the acute phase, defined as the 24-hour period between the first and second injections of LPS and 2) the perimortem phase, defined as the period between the second injection of LPS and IUFD. Changes in STV in both the acute and perimortem phases were evaluated using Friedman's test. A probability of