CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence.
CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence.
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DOI：
10.1038/bjc.2013.314
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发表时间：
2013-07-23
影响因子：
8.8
通讯作者：
Hibi T
中科院分区：
文献类型：
--
作者：
Hirata K;Suzuki H;Imaeda H;Matsuzaki J;Tsugawa H;Nagano O;Asakura K;Saya H;Hibi T
6-14%的患者在完成内镜下粘膜剥离（ESD）治疗后仍可能发生多发性早期胃癌（EGCs）；然而，目前还没有一种有效的预测复发的生物标志物。本研究探讨了功能性癌症干细胞标志物CD44变体9 （CD44v9）在原发性胃癌组织中的表达是否代表复发的指标。2008 - 2010年间88例接受ESD治疗的EGC患者入组，随访3年。免疫组化法检测初始EGCs组织中CD44v9的表达水平，比较CD44v9阳性组和CD44v9阴性组的复发率。并分析了粘蛋白表型和microRNA-21 （miR-21）和程序性细胞死亡蛋白4 （PDCD4）的表达。cd44v9阳性组EGC复发率明显高于cd44v9阴性组(风险比（HR）， 21.8；95%置信区间（CI）， 5.71-83.1)。然而，黏液蛋白表型、miR-21和PDCD4的表达并不能预测ESD后的复发。同时，胃萎缩程度也是多发性复发的重要标志（HR, 4.95; 95% CI, 1.30-18.8）。CD44变体9的表达是EGC复发的潜在预测标志物。
Multiple early gastric cancers (EGCs) may develop in 6–14% of patients even after achieving curative endoscopic submucosal dissection (ESD); however, a useful biomarker for predicting recurrence is not available. The present study investigated whether the expression of CD44 variant 9 (CD44v9), a functional cancer stem cell marker, in the primary gastric cancer tissue represents an indicator of recurrence. Eighty-eight patients who underwent ESD for EGC from 2008 to 2010 were enrolled and monitored for recurrence for 3 years. The expression levels of CD44v9 in the tissue of initial EGCs were evaluated by immunohistochemistry, and the recurrence rate was compared between CD44v9-positive and CD44v9-negative groups. The mucin phenotype and expression of microRNA-21 (miR-21) and programmed cell death protein 4 (PDCD4) were also analysed. The recurrence rate of EGC was significantly higher in the CD44v9-positive group than in the CD44v9-negative group (hazard ratio (HR), 21.8; 95% confidence interval (CI), 5.71–83.1). However, mucin phenotypes and the expression of miR-21 and PDCD4 did not predict recurrence after ESD. Meanwhile, grade of gastric atrophy was also identified as a significant marker of multiple recurrence (HR, 4.95; 95% CI, 1.30–18.8). CD44 variant 9 expression represents a potential predictive marker for recurrence in EGC.
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影响因子：
8
作者：
Saito, Y.;Suzuki, H.;Hibi, T.
通讯作者：
Hibi, T.
影响因子：
29.4
作者：
Huang, JQ;Sridhar, S;Hunt, RH
通讯作者：
Hunt, RH
影响因子：
9.3
作者：
Imaeda, H.;Iwao, Y.;Hibi, T.
通讯作者：
Hibi, T.
DOI：
10.1083/jcb.200310024
发表时间：
2004-06-21
期刊：
The Journal of cell biology
影响因子：
--
作者：
Nagano O;Murakami D;Hartmann D;De Strooper B;Saftig P;Iwatsubo T;Nakajima M;Shinohara M;Saya H
通讯作者：
Saya H
DOI：
10.1073/pnas.0703478104
发表时间：
2007-06-12
影响因子：
11.1
作者：
Dalerba, Piero;Dylla, Scott J.;Clarke, Michael F.
通讯作者：
Clarke, Michael F.