Heterocyclic α-helix mimetics for targeting protein-protein interactions
Heterocyclic α-helix mimetics for targeting protein-protein interactions
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DOI：
10.1016/j.bmcl.2007.05.075
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发表时间：
2007-08-15
影响因子：
2.7
通讯作者：
Rebek, Julius, Jr.
中科院分区：
文献类型：
--
作者：
Biros, Shannon M.;Moisan, Lionel;Rebek, Julius, Jr.
描述了使用逆电子需求Diels-Alder反应设计和合成α-螺旋肽模拟物。使用体外荧光偏振测定测试所得的基于哒嗪的文库破坏巴克/Bcl-X-L相互作用的效力。(c)2007爱思唯尔有限公司保留所有权利。
The design and synthesis of alpha-helix peptidomimetics using inverse electron demand Diels-Alder reactions is described. The potency of the resulting pyridazine-based library to disrupt the Bak/Bcl-X-L interaction was tested using an in vitro fluorescence polarization assay. (c) 2007 Elsevier Ltd. All rights reserved.