A removable silicone elastomer seal reduces granulation tissue growth and maintains the sterility of recording chambers for primate neurophysiology.
A removable silicone elastomer seal reduces granulation tissue growth and maintains the sterility of recording chambers for primate neurophysiology.
复制标题
可拆卸的硅胶弹性体密封件可减少肉芽组织的生长，并保持灵长类神经生理学记录室的无菌状态。
DOI：
10.1016/j.jneumeth.2007.11.026
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发表时间：
2008
影响因子：
3
通讯作者：
Gothard,KatalinM
中科院分区：
文献类型：
--
作者：
Spitler,KevinM;Gothard,KatalinM
连续急性神经生理学记录的开颅手术的无菌性的维持是严格和耗时的，然而对于有价值的实验动物的健康是至关重要的。我们开发了一种方法，在密封腔室中使用外科级硅橡胶（Silastic®）密封颅骨切开术。在这些条件下，颅骨切开术中的组织和腔室的内表面保持不被细菌占据。硅胶弹性体密封剂延缓了硬脑膜上肉芽组织的生长，并减少了维持神经生理记录理想条件所需的程序。
The maintenance of the sterility of craniotomies for serial acute neurophysiological recordings is exacting and time consuming yet is vital to the health of valuable experimental animals. We have developed a method to seal the craniotomy with surgical grade silicone elastomer (Silastic®) in a hermetically sealed chamber. Under these conditions the tissues in the craniotomy and the inside surface of the chamber remain unpopulated by bacteria. The silicone elastomer sealant retarded the growth of granulation tissue on the dura and reduced the procedures required to maintain ideal conditions for neurophysiological recordings.