Observation of anomalous diffusion in excised tissue by characterizing the diffusion-time dependence of the MR signal
Observation of anomalous diffusion in excised tissue by characterizing the diffusion-time dependence of the MR signal
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DOI：
10.1016/j.jmr.2006.08.009
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发表时间：
2006-12-01
影响因子：
2.2
通讯作者：
Blackband, Stephen J.
中科院分区：
文献类型：
--
作者：
Ozarslan, Evren;Basser, Peter J.;Blackband, Stephen J.
本文介绍了一种新的方法来表征生物组织中扩散加权磁共振（MR）信号的扩散-时间依赖性。该方法利用了无序介质中的扩散理论，其中两个参数，随机游走维数和谱维数，描述了从q空间MR实验获得的平均传播子的演变。这些参数估计，使用几种方案，从人类红细胞鬼和神经组织尸检样本获得的扩散MR波谱数据。实验表明，水在人体组织中的扩散是异常的，其中均方位移随扩散时间的变化慢于线性。这些观察结果与人体组织的分形微结构一致。在健康的人类神经组织和胶质母细胞瘤样本之间观察到的差异表明，所提出的方法可以提供一种新的、临床上有用的扩散MR对比形式。(c)2006年爱思唯尔公司All rights reserved.
This report introduces a novel method to characterize the diffusion-time dependence of the diffusion-weighted magnetic resonance (MR) signal in biological tissues. The approach utilizes the theory of diffusion in disordered media where two parameters, the random walk dimension and the spectral dimension, describe the evolution of the average propagators obtained from q-space MR experiments. These parameters were estimated, using several schemes, on diffusion MR spectroscopy data obtained from human red blood cell ghosts and nervous tissue autopsy samples. The experiments demonstrated that water diffusion in human tissue is anomalous, where the mean-square displacements vary slower than linearly with diffusion time. These observations are consistent with a fractal microstructure for human tissues. Differences observed between healthy human nervous tissue and glioblastoma samples suggest that the proposed methodology may provide a novel, clinically useful form of diffusion MR contrast. (c) 2006 Elsevier Inc. All rights reserved.