A COMPARISON OF THE EFFICACY OF KETOTIFEN (HC 20-511) WITH SODIUM CROMOGLYCATE (SCG) IN SKIN-TEST POSITIVE ASTHMA
A COMPARISON OF THE EFFICACY OF KETOTIFEN (HC 20-511) WITH SODIUM CROMOGLYCATE (SCG) IN SKIN-TEST POSITIVE ASTHMA
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DOI：
10.1111/j.1365-2125.1980.tb01791.x
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发表时间：
1980-01-01
影响因子：
3.4
通讯作者：
MAY, CS
中科院分区：
文献类型：
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作者：
CLARKE, CW;MAY, CS
在一项随机双盲交叉研究中，在35名皮肤试验阳性哮喘患者中发现1酮替芬（HC 20 - 511 Sandoz）1 mg每日2次，持续12周相当于色甘酸钠（SCG）20 mg每日4次，持续12周。2两种药物在每日峰值流速、日记卡评分和每月访视时肺功能测定的平均值方面无统计学显著差异。3每种药物有3例患者发生治疗失败，根据需要退出试验或增加短期泼尼松的严重哮喘判断。HC 20 - 511组10例患者和SCG组5例患者观察到4例镇静。5在接受SCG治疗的患者中观察到体重减轻，但在接受HC 20 - 511治疗的患者中未观察到体重减轻。
1 Ketotifen (HC 20‐511 Sandoz) 1 mg twice daily for 12 weeks was found to be equivalent to sodium cromoglycate (SCG) 20 mg four times daily for 12 weeks in 35 skin test positive asthmatic patients in a randomised double‐blind cross‐over study. 2 No statistically significant difference between the two drugs in mean values for daily peak flow rates, diary card scores and spirometry at monthly visits was demonstrated. 3 Treatment failures as judged by severe asthma requiring withdrawal from the trial or addition of short courses of prednisone occurred in three patients on each drug. 4 Sedation was noted by 10 patients onHC 20‐511 and 5 on SCG. 5 Weight loss was noted in those patients on SCG, but not those on HC 20‐511.