TREATMENT OF MALIGNANT PHEOCHROMOCYTOMA WITH COMBINATION CHEMOTHERAPY
TREATMENT OF MALIGNANT PHEOCHROMOCYTOMA WITH COMBINATION CHEMOTHERAPY
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DOI：
10.1161/01.hyp.7.3_pt_2.i18
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发表时间：
1985-01-01
期刊：
影响因子：
8.3
通讯作者：
AVERBUCH, SD
中科院分区：
文献类型：
--
作者：
KEISER, HR;GOLDSTEIN, DS;AVERBUCH, SD
3例快速进展、播散性恶性嗜铬细胞瘤患者接受环磷酰胺、长春新碱和达卡巴嗪联合化疗方案治疗，重复21- 28天为一个周期。所有三名患者在治疗的前几个周期内血压显著降低，体力状态改善。随访6 ~ 13个月，所有患者继续接受化疗，2例肿瘤进一步消退，1例病情稳定。他们的血压正常，很少或没有抗肾上腺素治疗。治疗耐受性良好;中度可逆性粒细胞减少症、神经毒性和一次肺炎发作是遇到的主要毒性。因此，联合化疗似乎是有效的症状恶性嗜铬细胞瘤。
Three patients with rapidly progressive, disseminated malignant pheochromocytoma were treated with a combination chemotherapeutic regimen consisting of cyclophosphamide, vincristine, and dacarbazine in repeated 21- to 28-day cycles. All three patients had a marked decrease in blood pressure and an improvement in performance status within the first few cycles of treatment. At a follow-up of 6 to 13 months all patients continue to receive chemotherapy with further regression of tumor in two and stable disease in one. Their blood pressure is normal with minimal or no antiadrenergic therapy. Therapy has been well tolerated; moderate reversible granulocytopenia, neurotoxicity, and one episode of pneumonitis have been the major toxicities encountered. Thus, combination chemotherapy appears to be effective for symptomatic malignant pheochromocytoma.