Non-Bilaterians as Model Systems for Tissue Mechanics
Non-Bilaterians as Model Systems for Tissue Mechanics
复制标题
非两侧对称人作为组织力学的模型系统
DOI：
10.1093/icb/icad074
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发表时间：
2023
影响因子：
2.6
通讯作者：
Prakash, Vivek N
中科院分区：
文献类型：
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作者：
Gooshvar, Setareh;Madhu, Gopika;Ruszczyk, Melissa;Prakash, Vivek N
在动物中，上皮组织是抵抗外部环境的屏障，提供对生物、化学和物理损伤的保护。根据生物体的生理和行为，这些组织会遇到不同类型的机械力，需要提供适当的适应性反应以确保成功。因此，理解不同背景下的组织力学是一个重要的研究领域。在这里，我们回顾了最近的组织力学发现在三个早期分歧的非两侧系统-Trichoplaxadhaerens，水螅，和Aureliaaurita。我们强调每种动物的简单的身体计划和生物学和独特的，快速的组织重塑现象，在其生理学中起着至关重要的作用。我们还讨论了这些系统中出现的小尺度现象的大尺度力学。最后，我们强调的潜力，这些非双侧动物模型系统在自下而上的方法，在组织力学的进一步调查。
In animals, epithelial tissues are barriers against the external environment, providing protection against biological, chemical, and physical damage. Depending on the organism’s physiology and behavior, these tissues encounter different types of mechanical forces and need to provide a suitable adaptive response to ensure success. Therefore, understanding tissue mechanics in different contexts is an important research area. Here, we review recent tissue mechanics discoveries in three early divergent non-bilaterian systems—Trichoplax adhaerens, Hydra vulgaris, andAurelia aurita. We highlight each animal’s simple body plan and biology and unique, rapid tissue remodeling phenomena that play a crucial role in its physiology. We also discuss the emergent large-scale mechanics in these systems that arise from small-scale phenomena. Finally, we emphasize the potential of these non-bilaterian animals to be model systems in a bottom-up approach for further investigation in tissue mechanics.