Post-Transcriptional Regulation in Skeletal Muscle Development, Repair, and Disease.
Post-Transcriptional Regulation in Skeletal Muscle Development, Repair, and Disease.
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DOI：
10.1016/j.molmed.2020.12.002
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发表时间：
2020-12
影响因子：
13.6
通讯作者：
K. Weskamp;B. Olwin;R. Parker
中科院分区：
文献类型：
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作者：
K. Weskamp;B. Olwin;R. Parker
骨骼肌的形成是一个复杂的过程，需要严格的时空控制的关键肌源性因素。新出现的证据表明，RNA加工对于这些因子的调节至关重要，并且多个转录后调节途径相互依赖和独立地工作，以在整个肌肉发育和修复过程中精确控制转录物。此外，这些途径的破坏与神经肌肉疾病有关，而RNA介导的疗法的最新发展在治疗这些疾病方面显示出巨大的前景。我们讨论了介导肌肉发育的重叠转录后调节途径，这些途径在神经肌肉疾病中是如何被破坏的，以及RNA介导的治疗方法的进展，这些方法为治疗这些疾病提供了一种新的方法。
Skeletal muscle formation is a complex process that requires tight spatiotemporal control of key myogenic factors. Emerging evidence suggests that RNA processing is crucial for the regulation of these factors, and that multiple post-transcriptional regulatory pathways work dependently and independently of one another to enable precise control of transcripts throughout muscle development and repair. Moreover, disruption of these pathways is implicated in neuromuscular disease, and the recent development of RNA-mediated therapies shows enormous promise in the treatment of these disorders. We discuss the overlapping post-transcriptional regulatory pathways that mediate muscle development, how these pathways are disrupted in neuromuscular disorders, and advances in RNA-mediated therapies that present a novel approach to the treatment of these diseases.