Maternal levels of dichlorodiphenyl-dichloroethylene (DDE) may increase weight and body mass index in adult female offspring
Maternal levels of dichlorodiphenyl-dichloroethylene (DDE) may increase weight and body mass index in adult female offspring
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DOI：
10.1136/oem.2008.041921
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发表时间：
2009-03-01
影响因子：
4.9
通讯作者：
Davis, S.
中科院分区：
文献类型：
--
作者：
Karmaus, W.;Osuch, J. R.;Davis, S.
目的：探讨1973年至1991年密歇根渔民队列中，产前暴露于多氯联苯（PCBs）和二氯二苯二氯乙烯（DDE）对成年雌性后代体重、身高和体重指数（BMI）的影响。方法：对来自密歇根fisher队列的259名母亲进行了研究。产前暴露于多氯联苯和DDE是通过外推产妇测量到妇女分娩的时间来估计的。在2000年共确定了213名20-50岁的女儿，其中83%的人在2001/02年（n=151）和2006/07年（n=129）两次重复调查中至少参加了一次。为了评估产前PCB和DDE暴露对人体测量的影响，使用了用于重复测量（2001/02和2006/07）和共用同一母亲的广义估计方程。我们控制了母亲的身高和身体质量指数，以及女儿的年龄、出生体重、母乳喂养和怀孕次数。结果：母亲身高和BMI是女儿身高、体重和BMI的显著预测因子。低出生体重(
Objectives: To investigate the effect of prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyl-dichloroethylene (DDE) on weight, height and body mass index (BMI) in adult female offspring of the Michigan fisheater cohort examined between 1973 and 1991.Methods: 259 mothers from the Michigan fisheater cohort were studied. Prenatal exposure to PCBs and DDE was estimated by extrapolating maternal measurements to the time that the women gave birth. 213 daughters aged 20-50 years in 2000 were identified and 83% of them participated in at least one of two repeated investigations in 2001/02 (n=151) and 2006/07 (n=129). To assess the effect of prenatal PCB and DDE exposure on anthropometric measurements, generalised estimating equations nested for repeated measurements (2001/02 and 2006/07) and for sharing the same mother were used. We controlled for maternal height and BMI and for daughters' age, birth weight, having been breastfed and number of pregnancies.Results: Maternal height and BMI were significant predictors of the daughters' height, weight and BMI. Low birth weight (