The Role of Circadian Rhythms in Muscular and Osseous Physiology and Their Regulation by Nutrition and Exercise.
The Role of Circadian Rhythms in Muscular and Osseous Physiology and Their Regulation by Nutrition and Exercise.
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DOI：
10.3389/fnins.2017.00063
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发表时间：
2017
影响因子：
4.3
通讯作者：
Shibata S
中科院分区：
文献类型：
--
作者：
Aoyama S;Shibata S
哺乳动物生物钟调节各种生理功能的昼夜周期。生物钟系统由下丘脑视交叉上核（SCN）的中枢时钟和周围组织的外周时钟组成。根据在几种组织中的昼夜节律转录组学研究的结果，大多数节律基因以组织特异性方式表达，并且受到组织特异性昼夜节律的影响。在这里，我们回顾了昼夜变化的肌肉骨骼功能和讨论的影响，昼夜节律钟对骨骼肌和骨骼的稳态。外围时钟不仅由SCN中的中央时钟的光刺激控制，而且还由外部提示（如进食和运动）控制。本文综述了摄食和运动对生物钟和肌肉骨骼功能日变化的影响。我们还讨论了时间营养和时间运动对昼夜节律紊乱和骨骼肌和骨骼内稳态失败的治疗潜力。
The mammalian circadian clock regulates the day and night cycles of various physiological functions. The circadian clock system consists of a central clock in the suprachiasmatic nucleus (SCN) of the hypothalamus and peripheral clocks in peripheral tissues. According to the results of circadian transcriptomic studies in several tissues, the majority of rhythmic genes are expressed in a tissue-specific manner and are influenced by tissue-specific circadian rhythms. Here we review the diurnal variations of musculoskeletal functions and discuss the impact of the circadian clock on homeostasis in skeletal muscle and bone. Peripheral clocks are controlled by not only photic stimulation from the central clock in the SCN but also by external cues, such as feeding and exercise. In this review, we discuss the effects of feeding and exercise on the circadian clock and diurnal variation of musculoskeletal functions. We also discuss the therapeutic potential of chrono-nutrition and chrono-exercise on circadian disturbances and the failure of homeostasis in skeletal muscle and bone.