Linkage limits the power of natural selection in Drosophila
Linkage limits the power of natural selection in Drosophila
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DOI：
10.1073/pnas.212277199
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发表时间：
2002-10-15
影响因子：
11.1
通讯作者：
Presgraves, DC
中科院分区：
文献类型：
--
作者：
Betancourt, AJ;Presgraves, DC
群体遗传学理论表明，自然选择的效力受到连锁选择的限制--一个位点的选择干扰了连锁位点的选择。这种干扰减缓了无性生殖基因组的适应性，并可能解释性的进化优势。在这里，我们测试的两个签名的约束所造成的性基因组中的连锁，通过使用255果蝇和果蝇simulans基因座的序列数据。我们发现，（i）蛋白质适应的速率在低重组的区域降低，和（h）在强选择的氨基酸位点的进化干扰在弱选择的，紧密连接的同义位点的最佳密码子使用。这些发现表明，即使在重组基因组时，连锁也限制了适应的速度和程度。
Population genetic theory shows that the efficacy of natural selection is limited by linkage-selection at one site interferes with selection at linked sites. Such interference slows adaptation in asexual genomes and may explain the evolutionary advantage of sex. Here, we test for two signatures of constraint caused by linkage in a sexual genome, by using sequence data from 255 Drosophila melanogaster and Drosophila simulans loci. We find that (i) the rate of protein adaptation is reduced in regions of low recombination, and (h) evolution at strongly selected amino acid sites interferes with optimal codon usage at weakly selected, tightly linked synonymous sites. Together these findings suggest that linkage limits the rate and degree of adaptation even in recombining genomes.